gene 538 words KG: EIF2A 2026-03-24
kind:genesection:genesstate:published
Contents

EIF2A Gene

🧬 Gene Info
Gene SymbolEIF2A
Full NameEukaryotic Translation Initiation Factor 2A
Chromosome3q27.1
FunctionBinds the 40S ribosomal subunit
PathwaysAkt, Apoptosis, Er Stress, Wnt
UniProt IDQ9Y5Q3
NCBI Gene ID27185
Ensembl IDENSG00000144895
OMIM609994
GeneCardsEIF2A
Human Protein AtlasEIF2A
Encoded ProteineIF2A
Associated Diseasesneurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsLRRK2, ATG16L1, RB1CC1, GABARAP, ERN1, STAT3
KG Connections534 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48

Related Analyses (5)

Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
ATF6 - Activating Transcription Factor 6
gene · KG edge: interacts_with
ATF4 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

EIF2A interacts_with LRRK2
EIF2A interacts_with ATG16L1
EIF2A interacts_with RB1CC1
EIF2A interacts_with GABARAP
EIF2A interacts_with ERN1
EIF2A interacts_with STAT3
EIF2A interacts_with IFNG
EIF2A interacts_with LC3
EIF2A interacts_with RPTOR
EIF2A interacts_with RB1