protein

EIF2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EIF2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

531Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

EIF2A is a protein involved in neurodegeneration research. Key relationships include: interacts with, activates, inhibits. Associated with ALS, Aging, Als. Connected to 296 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	EIF2A
Full Name	Eukaryotic Translation Initiation Factor 2A
Chromosome	3q27.1
Function	Binds the 40S ribosomal subunit
Pathways	Akt, Apoptosis, Er Stress, Wnt
UniProt ID	Q9Y5Q3
NCBI Gene ID	27185
Ensembl ID	ENSG00000144895
OMIM	609994
GeneCards	EIF2A
Human Protein Atlas	EIF2A
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	Actin, AKT, AKT1, AKT1S1, ALS, ALZHEIMER
KG Connections	530 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EIF2A — AlphaFold Q9Y5Q3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EIF2A["EIF2A"] -->|"regulates"| stress_granules["stress granules"]
    EIF2A["EIF2A"] -->|"interacts"| Cancer["Cancer"]
    EIF2A["EIF2A"] -->|"interacts"| Als["Als"]
    EIF2A["EIF2A"] -->|"interacts"| Ms["Ms"]
    EIF2A["EIF2A"] -->|"interacts"| Fibrosis["Fibrosis"]
    EIF2A["EIF2A"] -->|"interacts"| Aging["Aging"]
    OPTN["OPTN"] -->|"interacts"| EIF2A["EIF2A"]
    CASP3["CASP3"] -->|"interacts"| EIF2A["EIF2A"]
    AKT1["AKT1"] -->|"interacts"| EIF2A["EIF2A"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| EIF2A["EIF2A"]
    style EIF2A fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (348)

Target	Relation	Type	Str
protein synthesis	regulates	process	0.90
Endoplasmic Reticulum Stress	involved_in	process	0.85
Protein Translation	regulates	process	0.85
autophagy pathway	participates_in	pathway	0.80
Endoplasmic Reticulum Stress	biomarker_for	process	0.75
Als	activates	disease	0.75
oxidative stress response	participates_in	pathway	0.70
stress granules	regulates	process	0.70
Aging	interacts_with	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	contributes_to	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Fibrosis	interacts_with	disease	0.65
Heart Failure	inhibits	disease	0.65
Inflammation	interacts_with	disease	0.65
Als	regulates	disease	0.65
Ms	activates	disease	0.65
Cancer	regulates	disease	0.65
Ischemia	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Cancer	inhibits	disease	0.65
Fibrosis	regulates	disease	0.65
Als	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Ms	inhibits	disease	0.65
Ms	interacts_with	disease	0.65
Aging	regulates	disease	0.65
Alzheimer	inhibits	disease	0.65
Cancer	interacts_with	disease	0.65
HSPA5	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
MAPK14	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
TIA1	associated_with	gene	0.60
RRAGB	interacts_with	gene	0.60
AKT	activates	gene	0.60
RRAGA	interacts_with	gene	0.60

Incoming (183)

Source	Relation	Type	Str
TMTD	phosphorylates	compound	0.90
Stress Granules	phosphorylates	process	0.85
DTG	upregulates	drug	0.85
PERK	phosphorylates	protein	0.85
rapamycin	targets	drug	0.70
RICTOR	interacts_with	gene	0.60
MAP1LC3A	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
DDIT3	phosphorylates	entity	0.60
DEPTOR	phosphorylates	entity	0.60
EGF	phosphorylates	entity	0.60
EGFR	phosphorylates	entity	0.60
OPTINEURIN	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
CDH1	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
ATG	associated_with	gene	0.60
PHGDH	activates	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
AMYLOID	inhibits	gene	0.60
MTOR	activates	gene	0.60
ATG	activates	gene	0.60
ATG12	activates	gene	0.60
AKT1	regulates	gene	0.60
HSP27	inhibits	gene	0.60
MITOPHAGY	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
CANCER	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AMPK	activates	gene	0.60
GABA	interacts_with	gene	0.60
AKT1S1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
CYP1A1	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
eIF2alpha Dephosphorylation Threshold Prevents Pro-Apoptotic	0.445	-	What is the minimum effective dose of tr

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EIF2A in their description or question text

No additional research found