gene 958 words KG: SLC7A1 2026-04-01
kind:genesection:genestopic:alzheimerstopic:parkinsons
Contents

SLC7A1 Gene

🧬 Gene Info
Gene SymbolSLC7A1
Chromosome19p13.2
Protein TypeTransporter
Functionis a high-affinity transmembrane transporter that mediates cellular uptake of cationic amino acids, particularly L-arginine, L-lysine, and L-ornithine[@mann2003].
Amino Acids629 aa
Exons14
PathwaysFerroptosis
UniProt IDP30825
NCBI Gene ID6541
Ensembl IDENSG00000147614
GeneCardsSLC7A1
Human Protein AtlasSLC7A1
Official Full NameSolute Carrier Family 7 Member 1
AliasCAT1, CAT-1, ATRC1
Transcript Length~4.2 kb
Associated DiseasesAlzheimer's disease, Parkinson's disease
KG Connections23 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
CYP46A1 Overexpression Gene Therapy
Score: 0.63
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
Blood-Brain Barrier SPM Shuttle System
Score: 0.55

Related Analyses (7)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

See Also (15)

TRIM28 (KAP1) Protein
protein · KG edge: co_discussed
Lysosome Dysfunction in Neurodegeneration
mechanism · KG edge: co_discussed
NRF2 Activator Therapy
idea · KG edge: co_discussed
TRIM2 Gene (Tripartite Motif Containing 2)
gene · KG edge: co_discussed
STING Gene
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

SLC7A1 co_discussed SLC7A11
SLC7A1 co_discussed STING
SLC7A1 co_discussed STAT6
SLC7A1 co_discussed TRIM2
SLC7A1 co_discussed TRIM28
SLC7A1 mediates Boronophenylalanine
SLC7A1 biomarker_for Cervical Cancer
SLC7A1 expressed_in HeLa
SLC7A1 inhibits Ferroptosis
SLC7A1 regulates Ferroptosis