| Gene Symbol | HDAC5 |
| Full Name | Histone Deacetylase 5 |
| Chromosome | 17q21.31 |
| Protein Family | Class IIa histone deacetylases |
| Function | Histone deacetylation: HDAC5 deacetylates histone H3 and H4 tails, creating a chromatin environment that suppresses transcription |
| Primary Expression | the brain, where it plays critical roles in synaptic plasticity, memory formation, stress responses, and n |
| Subcellular Localization | Nucleus (basal) and cytoplasm (signal-dependent) |
| Molecular Weight | 112 kDa |
| Amino Acids | 1122 aa |
| Pathways | NF-κB |
| UniProt ID | Q9UQL6 |
| NCBI Gene ID | 10014 |
| Ensembl ID | ENSG00000108840 |
| OMIM | 605315 |
| GeneCards | HDAC5 |
| Human Protein Atlas | HDAC5 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, Huntington's disease |
| Interactions | STAT6, SLC7A11, TRIM28, HDAC7, TNF, HDAC9 |
| KG Connections | 76 knowledge graph edges |
| Databases | GeneCardsHPASTRING |