gene 1,049 words KG: SMARCA4 2026-03-24
kind:genesection:genesstate:published
Contents

SMARCA4

🧬 Gene Info
Gene SymbolSMARCA4
Chromosome19p13.2
FunctionATP-dependent chromatin remodeling ATPase
Primary Expressionthe cerebral cortex, hippocampus, and cerebellum
Amino Acids1647 aa
Exons35
Gene TypeProtein-coding
PathwaysEpigenetic
NCBI Gene ID6597
Ensembl IDENSG00000127616
GeneCardsSMARCA4
Human Protein AtlasSMARCA4
HGNC ID11100
ProteinBRG1 protein
Key DomainsQLQ, HSA, BRK, DEXDc, HELICc, Bromodomain
Associated DiseasesAD, ALI, AMI, Als, CRC, Cancer
Known Drugs/Compoundsrapamycin
InteractionsARID1A, APOB, TERT, IDH1, MET, JUN
SciDEX HypothesesChromatin Remodeling-Mediated Nutrient Sensing Res
KG Connections325 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (5)

Chromatin Remodeling-Mediated Nutrient Sensing Restoration
Score: 0.62
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.38
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.38

Related Analyses (3)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.46

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
BRG1 Gene
gene · KG edge: activates
BECN1 Gene
gene · KG edge: activates
AXIN2 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

SMARCA4 therapeutic_target TERT
SMARCA4 therapeutic_target JUN
SMARCA4 associated_with EEF1A1
SMARCA4 therapeutic_target MCL1
SMARCA4 therapeutic_target IDH1
SMARCA4 therapeutic_target APOB
SMARCA4 therapeutic_target MDM4
SMARCA4 therapeutic_target VEGFA
SMARCA4 therapeutic_target MET
SMARCA4 therapeutic_target FZD7