gene 971 words KG: SV2A 2026-03-20
kind:genesection:genesstate:published
Contents

SV2A — Synaptic Vesicle Protein 2A

🧬 Gene Info
Gene SymbolSV2A
Full NameSynaptic Vesicle Protein 2A
Chromosome1p31.1
Protein TypeTransporter
FunctionSV2A is an integral membrane protein localized to synaptic vesicles
Subcellular Localizationsynaptic vesicles:
PathwaysSynaptic vesicle formation
UniProt IDQ9H0Y5
NCBI Gene ID9902
Ensembl IDENSG00000159166
OMIM158621
GeneCardsSV2A
Human Protein AtlasSV2A
DiseaseMechanism
Alzheimer's DiseaseSV2A expression reduced in AD brains; involved in synaptic loss
Associated DiseasesALS
InteractionsProteins, SNAP25, SYNAPTOPHYSIN, GAP43, PSD95, GFAP
KG Connections34 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.37
SASP-Mediated Complement Cascade Amplification
Score: 0.70
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51

Related Analyses (18)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (1)

Experiment Scoring Methodology
clinical · proposed · Score: 0.40

See Also (9)

Proteins
index · KG edge: interacts_with
Neuroplasticity in Neurodegenerative Disease
mechanism · KG edge: involved_in
Packard Center for ALS Research
institution · KG edge: associated_with
DLG4 Gene
gene · KG edge: associated_with
GAP43 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SV2A involved_in neuroplasticity
SV2A associated_with GAP43
SV2A associated_with PSD95
SV2A associated_with SYNAPTOPHYSIN
SV2A expressed_in Amygdala
SV2A expressed_in Striatum
SV2A associated_with AND
SV2A associated_with SAPAP3
SV2A interacts_with Anxiety
SV2A associated_with ALS