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gene 971 words KG: SV2A
Contents

SV2A — Synaptic Vesicle Protein 2A

🧬 Gene Info
Gene SymbolSV2A
Full NameSynaptic Vesicle Protein 2A
Chromosome1p31.1
Protein TypeTransporter
FunctionSV2A is an integral membrane protein localized to synaptic vesicles
Subcellular Localizationsynaptic vesicles:
PathwaysSynaptic vesicle formation
UniProt IDQ9H0Y5
NCBI Gene ID9902
Ensembl IDENSG00000159166
OMIM158621
GeneCardsSV2A
Human Protein AtlasSV2A
Associated DiseasesAD, ALS
InteractionsANXIETY, GAP43, GFAP, Proteins, PSD95, SAPAP3
KG Connections36 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (20)

Microglia-Derived Extracellular Vesicle Engineering for Targ
Score: 0.48SASP-Mediated Complement Cascade Amplification
Score: 0.82Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Extracellular Vesicle Biogenesis Modulation
Score: 0.58Synaptic Vesicle Tau Capture Inhibition
Score: 0.58Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.57Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51

Related Analyses (18)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedPerivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Experiment Scoring Methodology
clinical · proposed · Score: 0.40

See Also (9)

Synaptophysin - Synaptic Biomarker
biomarker · KG edge: associated_withHippocampus
brain · KG edge: expressed_inStriatum
brain · KG edge: expressed_inNeurodegeneration
disease · KG edge: implicated_inGAP43 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SV2A associated_with GAP43
SV2A associated_with PSD95
SV2A associated_with SYNAPTOPHYSIN
SV2A expressed_in Amygdala
SV2A expressed_in Striatum
SYNAPTOPHYSIN interacts_with SV2A
GAP43 interacts_with SV2A
PSD95 interacts_with SV2A
SV2A co_expressed_with SYP
SV2A correlates_with AΒ

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