Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL1R1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IL1R1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, associated with, implicated in. Associated with Als, Inflammation, Ms. Connected to 17 entities in the SciDEX knowledge graph.
| Gene Symbol | IL1R1 |
| Full Name | Interleukin 1 Receptor Type 1 |
| Chromosome | 2q12 |
| Protein Type | Receptor |
| Function | IL-1R1 mediates the potent pro-inflammatory effects of IL-1 cytokines in the central nervous system: |
| Molecular Weight | 80 kDa |
| Amino Acids | 319 aa |
| Pathways | NF-κB, MAPK |
| UniProt ID | [P01589](https://www.uniprot.org/uniprot/P01589) |
| Ensembl ID | ENSG00000115594 |
| GeneCards | IL1R1 |
| Human Protein Atlas | IL1R1 |
| Associated Diseases | Als, Infection, Inflammation, disease |
| Interactions | SERPINA3, Rb, Il-10, TNFR1, IFN, Interleukin |
| KG Connections | 60 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
IL1R1["<b>IL1R1</b>"]
Ms{"Ms"}
IL1R1 -->|"expressed in"| Ms
Neuroinflammation{"Neuroinflammation"}
IL1R1 -->|"expressed in"| Neuroinflammation
Inflammation{"Inflammation"}
IL1R1 -->|"expressed in"| Inflammation
NEUROINFLAMMATION["NEUROINFLAMMATION"]
IL1R1 -->|"expressed in"| NEUROINFLAMMATION
SERPINA3["SERPINA3"]
IL1R1 -->|"activates"| SERPINA3
S100A9["S100A9"]
IL1R1 -->|"expressed in"| S100A9
neurodegeneration["neurodegeneration"]
IL1R1 -->|"implicated in"| neurodegeneration
IL1RN["IL1RN"]
IL1RN -->|"expressed in"| IL1R1
MICROGLIA["MICROGLIA"]
MICROGLIA -->|"expressed in"| IL1R1
MIRNAS["MIRNAS"]
MIRNAS -->|"expressed in"| IL1R1
ASTROCYTES["ASTROCYTES"]
ASTROCYTES -->|"expressed in"| IL1R1
MMP3["MMP3"]
MMP3 -->|"expressed in"| IL1R1
style IL1R1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Encephalitis | contributes_to | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Neuroinflammation | expressed_in | disease | 0.65 |
| Inflammation | expressed_in | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Als | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Obesity | expressed_in | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| SERPINA3 | activates | gene | 0.60 |
| S100A9 | expressed_in | gene | 0.60 |
| Nfkb | associated_with | protein | 0.60 |
| Rb | expressed_in | protein | 0.60 |
| Rb | activates | protein | 0.60 |
| Il-10 | activates | protein | 0.60 |
| TNFR1 | activates | gene | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| NEUROINFLAMMATION | expressed_in | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| IFN | activates | gene | 0.60 |
| Interleukin | activates | protein | 0.60 |
| Cytokine | activates | protein | 0.60 |
| Il-1 | contributes_to | protein | 0.60 |
| App | expressed_in | protein | 0.60 |
| Immune Response | interacts_with | pathway | 0.60 |
| Il-1 | interacts_with | protein | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| Microglia | activates | cell_type | 0.60 |
| Macrophage | activates | cell_type | 0.60 |
| Il-1 | activates | protein | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| Spinal Cord | expressed_in | brain_region | 0.55 |
| disease | associated_with | disease | 0.50 |
| Infection | associated_with | disease | 0.50 |
| IL-1 | associated_with | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| IL1RN | expressed_in | gene | 0.60 |
| MMP3 | expressed_in | gene | 0.60 |
| TCF7L2 | interacts_with | gene | 0.60 |
| OVERVIEW | associated_with | gene | 0.60 |
| TOLLIP | regulates | gene | 0.60 |
| IRAK1 | regulates | gene | 0.60 |
| CCR2 | activates | gene | 0.60 |
| MICROGLIA | expressed_in | gene | 0.60 |
| MIRNAS | expressed_in | gene | 0.60 |
| ASTROCYTES | expressed_in | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| IL-1 | contributes_to | gene | 0.60 |
| GENES | contributes_to | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| AND | contributes_to | gene | 0.60 |
| FOSL2 | associated_with | gene | 0.60 |
| IL-10 | activates | gene | 0.60 |
| IL-1 | activates | gene | 0.60 |
| INOS | activates | gene | 0.60 |
| CYTOKINES | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||