gene

IL1R1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL1R1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections

0Hypotheses

2Analyses

47Outgoing

20Incoming

0Experiments

2Debates

Summary

IL1R1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, associated with, implicated in. Associated with Als, Inflammation, Ms. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL1R1
Full Name	Interleukin 1 Receptor Type 1
Chromosome	2q12
Protein Type	Receptor
Function	IL-1R1 mediates the potent pro-inflammatory effects of IL-1 cytokines in the central nervous system:
Subcellular Localization	</b></td><td>Cell membrane (type I transmembrane)</td></tr>
Molecular Weight	80 kDa
Amino Acids	319 aa
Pathways	NF-κB, MAPK
UniProt ID	[P01589](https://www.uniprot.org/uniprot/P01589)
Ensembl ID	ENSG00000115594
GeneCards	IL1R1
Human Protein Atlas	IL1R1
Associated Diseases	Als, disease, Infection, Inflammation, microglial_priming, Microglial priming
Interactions	CCR2, Cytokine, IFN, Il-1, IL-1, Il-10
KG Connections	67 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

Interleukin-1 Receptor Type 1 Protein

protein · 1175 words

→

IL1R1 Gene

gene · 692 words

→

Pathway Diagram

graph TD
    IL1R1["IL1R1"]
    Ms{"Ms"}
    IL1R1 -->|"expressed in"| Ms
    Neuroinflammation{"Neuroinflammation"}
    IL1R1 -->|"expressed in"| Neuroinflammation
    Inflammation{"Inflammation"}
    IL1R1 -->|"expressed in"| Inflammation
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    IL1R1 -->|"expressed in"| NEUROINFLAMMATION
    SERPINA3["SERPINA3"]
    IL1R1 -->|"activates"| SERPINA3
    S100A9["S100A9"]
    IL1R1 -->|"expressed in"| S100A9
    neurodegeneration["neurodegeneration"]
    IL1R1 -->|"implicated in"| neurodegeneration
    IL1RN["IL1RN"]
    IL1RN -->|"expressed in"| IL1R1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"expressed in"| IL1R1
    MIRNAS["MIRNAS"]
    MIRNAS -->|"expressed in"| IL1R1
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"expressed in"| IL1R1
    MMP3["MMP3"]
    MMP3 -->|"expressed in"| IL1R1
    style IL1R1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (47)

Target	Relation	Type	Str
Microglial priming	mediates	phenotype	0.90
C1q expression	activates	process	0.70
Microglial priming	causes	phenotype	0.70
microglial_priming	regulates	phenotype	0.70
TNFRSF1A	associated_with	gene	0.70
microglial_priming	causes	phenotype	0.70
positive_feedback_loops	modulates	mechanism	0.70
microglial_priming	mediates	phenotype	0.70
Inflammation	associated_with	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
Cancer	interacts_with	disease	0.65
Encephalitis	contributes_to	disease	0.65
Ms	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Obesity	expressed_in	disease	0.65
Neuroinflammation	activates	disease	0.65
Interleukin	activates	protein	0.60
Il-1	contributes_to	protein	0.60
App	expressed_in	protein	0.60
SERPINA3	activates	gene	0.60
Immune Response	interacts_with	pathway	0.60
Il-1	interacts_with	protein	0.60
Rb	expressed_in	protein	0.60
S100A9	expressed_in	gene	0.60
Oxidative Stress	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Macrophage	activates	cell_type	0.60
Cytokine	activates	protein	0.60
Il-1	activates	protein	0.60
Immune Response	regulates	pathway	0.60
microglia	expressed_in	cell_type	0.60
NEUROINFLAMMATION	expressed_in	gene	0.60
Il-10	activates	protein	0.60
IFN	activates	gene	0.60
Rb	activates	protein	0.60
Nfkb	associated_with	protein	0.60
TNFR1	activates	gene	0.60
GENES	associated_with	gene	0.60
neuroinflammation	activates	disease	0.60
Spinal Cord	expressed_in	brain_region	0.55
disease	associated_with	disease	0.50
Infection	associated_with	disease	0.50
IL-1	associated_with	concept	0.50

Incoming (20)

Source	Relation	Type	Str
INFLAMMATION	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
GENES	contributes_to	gene	0.60
INFLAMMATION	activates	gene	0.60
FOSL2	associated_with	gene	0.60
IL-10	activates	gene	0.60
IL-1	activates	gene	0.60
INOS	activates	gene	0.60
CYTOKINES	regulates	gene	0.60
IL1RN	expressed_in	gene	0.60
MMP3	expressed_in	gene	0.60
TCF7L2	interacts_with	gene	0.60
OVERVIEW	associated_with	gene	0.60
TOLLIP	regulates	gene	0.60
IRAK1	regulates	gene	0.60
CCR2	activates	gene	0.60
MICROGLIA	expressed_in	gene	0.60
MIRNAS	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
IL-1	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Can circadian interventions reverse microglial priming independent of sleep disr

chronobiology | 2026-04-08 | 7 hypotheses Top: 0.455

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.658

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

While the study demonstrates both NF-κB pathway activation and increased C1qa ex

closed · Rounds: 4 · Score: 0.74 · 2026-04-21

Can circadian interventions reverse microglial priming independent of sleep disr

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning IL1R1 in their description or question text

No additional research found