gene

IL1R1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL1R1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections
0Hypotheses
0Analyses
39Outgoing
21Incoming

Summary

IL1R1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, associated with, implicated in. Associated with Als, Inflammation, Ms. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolIL1R1
Full NameInterleukin 1 Receptor Type 1
Chromosome2q12
Protein TypeReceptor
FunctionIL-1R1 mediates the potent pro-inflammatory effects of IL-1 cytokines in the central nervous system:
Molecular Weight80 kDa
Amino Acids319 aa
PathwaysNF-κB, MAPK
UniProt ID[P01589](https://www.uniprot.org/uniprot/P01589)
Ensembl IDENSG00000115594
GeneCardsIL1R1
Human Protein AtlasIL1R1
Associated DiseasesAls, Infection, Inflammation, disease
InteractionsSERPINA3, Rb, Il-10, TNFR1, IFN, Interleukin
KG Connections60 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

IL1R1 Gene

gene · 692 words

IL1RAP — Interleukin-1 receptor accessory protein

gene · 3150 words

NICASTRIN Gene

gene · 3072 words

IL1B — Interleukin-1 Beta

protein · 1526 words

IL1A — Interleukin 1 Alpha

gene · 1318 words

Interleukin-1 Receptor Type 1 Protein

protein · 1175 words

Pathway Diagram

graph TD
    IL1R1["<b>IL1R1</b>"]
    Ms{"Ms"}
    IL1R1 -->|"expressed in"| Ms
    Neuroinflammation{"Neuroinflammation"}
    IL1R1 -->|"expressed in"| Neuroinflammation
    Inflammation{"Inflammation"}
    IL1R1 -->|"expressed in"| Inflammation
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    IL1R1 -->|"expressed in"| NEUROINFLAMMATION
    SERPINA3["SERPINA3"]
    IL1R1 -->|"activates"| SERPINA3
    S100A9["S100A9"]
    IL1R1 -->|"expressed in"| S100A9
    neurodegeneration["neurodegeneration"]
    IL1R1 -->|"implicated in"| neurodegeneration
    IL1RN["IL1RN"]
    IL1RN -->|"expressed in"| IL1R1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"expressed in"| IL1R1
    MIRNAS["MIRNAS"]
    MIRNAS -->|"expressed in"| IL1R1
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"expressed in"| IL1R1
    MMP3["MMP3"]
    MMP3 -->|"expressed in"| IL1R1
    style IL1R1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

TargetRelationTypeStr
Encephalitiscontributes_todisease0.65
Msexpressed_indisease0.65
Neuroinflammationexpressed_indisease0.65
Inflammationexpressed_indisease0.65
Alsassociated_withdisease0.65

Incoming (21)

SourceRelationTypeStr
IL1RNexpressed_ingene0.60
MMP3expressed_ingene0.60
TCF7L2interacts_withgene0.60
OVERVIEWassociated_withgene0.60
TOLLIPregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found