Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about apoa2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | APOA2 |
| Full Name | Apolipoprotein A2 |
| Chromosome | 1q23.3 |
| Function | The APOA2 gene encodes Apolipoprotein A2, the second most abundant apolipoprotein in high-density lipoprotein (HDL) particles. |
| Molecular Weight | 17 kDa |
| Amino Acids | 77 aa |
| UniProt ID | APOA2 |
| NCBI Gene ID | 336 |
| Ensembl ID | ENSG00000158874 |
| OMIM | 107670 |
| GeneCards | APOA2 |
| Human Protein Atlas | APOA2 |
| Associated Diseases | Parkinson, Als, Ms, neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
APOA2["APOA2"]
APOA2 -.biomarker for.-> Carcinoma["Carcinoma"]
APOA2 -.biomarker for.-> Tumor["Tumor"]
APOA2 -->|"regulates"| Cardiovascular["Cardiovascular"]
APOA2 -->|"regulates"| Diabetes["Diabetes"]
APOA2 -->|"regulates"| Metabolic_Syndrome["Metabolic Syndrome"]
APOA2 -->|"regulates"| Als["Als"]
APOA2 -->|"regulates"| Atherosclerosis["Atherosclerosis"]
APOA2 -->|"regulates"| Inflammation["Inflammation"]
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| APOA2
TCF7L2["TCF7L2"] -->|"interacts"| APOA2
IL_6["IL-6"] -->|"interacts"| APOA2
INFLAMMATION["INFLAMMATION"] -->|"regulates"| APOA2
GENES["GENES"] -->|"regulates"| APOA2| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Carcinoma | biomarker_for | disease | 0.65 |
| Tumor | biomarker_for | disease | 0.65 |
| Cardiovascular | regulates | disease | 0.65 |
| Diabetes | regulates | disease | 0.65 |
| Metabolic Syndrome | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Atherosclerosis | regulates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| LGALS3 | associated_with | gene | 0.60 |
| CSNK2A1 | associated_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| APOC2 | associated_with | gene | 0.60 |
| MCC | associated_with | gene | 0.60 |
| CAT | associated_with | gene | 0.60 |
| APOA1 | associated_with | gene | 0.60 |
| STX4 | associated_with | gene | 0.60 |
| HSPB1 | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 0.60 |
| Lipid Metabolism | associated_with | pathway | 0.60 |
| Cholesterol | associated_with | pathway | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| Oxidative Stress | regulates | pathway | 0.60 |
| benchmark_ot_ad_answer_key:APOA2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| STX4 | associated_with | gene | 0.60 |
| LDLR | associated_with | gene | 0.60 |
| LGALS3 | associated_with | gene | 0.60 |
| APOE4 | associated_with | gene | 0.60 |
| TCF7L2 | interacts_with | gene | 0.60 |
| HSPB1 | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| ACOX1 | associated_with | gene | 0.60 |
| OXIDATIVE STRESS | regulates | gene | 0.60 |
| IL-6 | interacts_with | gene | 0.60 |
| INFLAMMATION | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| benchmark_ot_ad_answer_key:APOA2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||