gene 762 words KG: TMEM175 2026-03-21
kind:genesection:genesstate:published
Contents

TMEM175 Gene

🧬 Gene Info
Gene SymbolTMEM175
Protein TypeProtein
Functionis a lysosomal potassium channel that plays critical roles in neuronal function and survival.
Subcellular Localizationlysosomes and late endosomes[@gomezsuaga2019]. The channel maintains lysosomal membrane potential, which is essential fo
Amino Acids522 aa
PathwaysLysosomal pH Homeostasis
UniProt IDSearch UniProt
GeneCardsTMEM175
Human Protein AtlasTMEM175
Associated DiseasesAls, Ms, Neurodegeneration, Parkinson, Parkinson'S Disease
InteractionsJUN, AKT, VCP, PARKINSON, PARKINSON'S DISEASE, LYSOSOME
KG Connections138 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (15)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51

Related Analyses (4)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Lysosome Dysfunction in Neurodegeneration
mechanism · KG edge: implicated_in
LAMP2 Gene
gene · KG edge: inhibits
Lysosomal Associated Membrane Protein 1 (LAMP1)
gene · KG edge: associated_with
JUN Gene
gene · KG edge: inhibits
CTSB Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TMEM175 contributes_to LAMP1
TMEM175 associated_with REM sleep behavior disorder
TMEM175 contributes_to TFEB
TMEM175 contributes_to GBA
TMEM175 inhibits JUN
TMEM175 regulates Lysosomal Function
TMEM175 involved_in Lysosomal pH Homeostasis
TMEM175 inhibits AKT
TMEM175 associated_with SMPD1
TMEM175 associated_with CTSD