Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IDH3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IDH3A is a gene implicated in neurodegeneration research. Key relationships include: inhibits, regulates, implicated in. Associated with Als, Cardiac, Fibrosis. Connected to 15 entities in the SciDEX knowledge graph.
| Gene Symbol | IDH3A |
| Full Name | Isocitrate Dehydrogenase 3 Alpha |
| Chromosome | 7q32.2 |
| Protein Type | Enzyme |
| Function | is a critical mitochondrial enzyme in the tricarboxylic acid (TCA) cycle that plays a pivotal role in cellular energy metabolism. |
| Subcellular Localization | Mitochondrial matrix |
| Molecular Weight | ~46 kDa |
| Amino Acids | 413 aa |
| Pathways | Autophagy, Histone Modification |
| GeneCards | IDH3A |
| Human Protein Atlas | IDH3A |
| Protein Length | 413 amino acids |
| Enzyme Classification | EC 1.1.1.41 (NAD+-dependent) |
| Year | Discovery |
| 1970s | IDH3A enzyme characterized |
| Associated Diseases | neurodegeneration |
| Interactions | TPM1, BNIP3, AND, MITOPHAGY, BCL-2, NAD |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
IDH3A["<b>IDH3A</b>"]
Fibrosis{"Fibrosis"}
IDH3A -->|"inhibits"| Fibrosis
Als{"Als"}
IDH3A -->|"inhibits"| Als
Cardiac{"Cardiac"}
IDH3A -->|"regulates"| Cardiac
Ischemia{"Ischemia"}
IDH3A -->|"regulates"| Ischemia
Apoptosis(["Apoptosis"])
IDH3A -->|"inhibits"| Apoptosis
Autophagy(["Autophagy"])
IDH3A -->|"regulates"| Autophagy
Histone_Modification(["Histone Modification"])
IDH3A -->|"regulates"| Histone_Modification
Mitophagy(["Mitophagy"])
IDH3A -->|"inhibits"| Mitophagy
neurodegeneration["neurodegeneration"]
IDH3A -->|"implicated in"| neurodegeneration
BNIP3["BNIP3"]
BNIP3 -->|"inhibits"| IDH3A
MITOPHAGY["MITOPHAGY"]
MITOPHAGY -->|"inhibits"| IDH3A
TPM1["TPM1"]
TPM1 -->|"inhibits"| IDH3A
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"inhibits"| IDH3A
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"regulates"| IDH3A
BCL_2["BCL-2"]
BCL_2 -->|"inhibits"| IDH3A
style IDH3A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Fibrosis | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Cardiac | regulates | disease | 0.65 |
| Ischemia | regulates | disease | 0.65 |
| GAIN | regulates | gene | 0.60 |
| TPM1 | inhibits | gene | 0.60 |
| BNIP3 | inhibits | gene | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Histone Modification | regulates | pathway | 0.60 |
| Mitophagy | inhibits | pathway | 0.60 |
| AND | inhibits | gene | 0.60 |
| MITOPHAGY | inhibits | gene | 0.60 |
| BCL-2 | inhibits | gene | 0.60 |
| NAD | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||