gene

IDH3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IDH3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections
0Hypotheses
0Analyses
17Outgoing
6Incoming

Summary

IDH3A is a gene implicated in neurodegeneration research. Key relationships include: inhibits, regulates, implicated in. Associated with Als, Cardiac, Fibrosis. Connected to 15 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolIDH3A
Full NameIsocitrate Dehydrogenase 3 Alpha
Chromosome7q32.2
Protein TypeEnzyme
Functionis a critical mitochondrial enzyme in the tricarboxylic acid (TCA) cycle that plays a pivotal role in cellular energy metabolism.
Subcellular LocalizationMitochondrial matrix
Molecular Weight~46 kDa
Amino Acids413 aa
PathwaysAutophagy, Histone Modification
GeneCardsIDH3A
Human Protein AtlasIDH3A
Protein Length413 amino acids
Enzyme ClassificationEC 1.1.1.41 (NAD+-dependent)
YearDiscovery
1970sIDH3A enzyme characterized
Associated Diseasesneurodegeneration
InteractionsTPM1, BNIP3, AND, MITOPHAGY, BCL-2, NAD
KG Connections23 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

idh3a

gene · 769 words

TPM1 — Tropomyosin 1

gene · 1701 words

IDH3A Protein

protein · 791 words

Genes

index · 271 words

Pathway Diagram

graph TD
    IDH3A["<b>IDH3A</b>"]
    Fibrosis{"Fibrosis"}
    IDH3A -->|"inhibits"| Fibrosis
    Als{"Als"}
    IDH3A -->|"inhibits"| Als
    Cardiac{"Cardiac"}
    IDH3A -->|"regulates"| Cardiac
    Ischemia{"Ischemia"}
    IDH3A -->|"regulates"| Ischemia
    Apoptosis(["Apoptosis"])
    IDH3A -->|"inhibits"| Apoptosis
    Autophagy(["Autophagy"])
    IDH3A -->|"regulates"| Autophagy
    Histone_Modification(["Histone Modification"])
    IDH3A -->|"regulates"| Histone_Modification
    Mitophagy(["Mitophagy"])
    IDH3A -->|"inhibits"| Mitophagy
    neurodegeneration["neurodegeneration"]
    IDH3A -->|"implicated in"| neurodegeneration
    BNIP3["BNIP3"]
    BNIP3 -->|"inhibits"| IDH3A
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"inhibits"| IDH3A
    TPM1["TPM1"]
    TPM1 -->|"inhibits"| IDH3A
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"inhibits"| IDH3A
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"regulates"| IDH3A
    BCL_2["BCL-2"]
    BCL_2 -->|"inhibits"| IDH3A
    style IDH3A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

TargetRelationTypeStr
Fibrosisinhibitsdisease0.65
Alsinhibitsdisease0.65
Cardiacregulatesdisease0.65
Ischemiaregulatesdisease0.65
GAINregulatesgene0.60

Incoming (6)

SourceRelationTypeStr
BNIP3inhibitsgene0.60
TPM1inhibitsgene0.60
MITOPHAGYinhibitsgene0.60
APOPTOSISinhibitsgene0.60
AUTOPHAGYregulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found