gene 533 words KG: TRPV1 2026-03-24
kind:genesection:genesstate:published
Contents

TRPV1 Gene

🧬 Gene Info
Gene SymbolTRPV1
Full NameTransient Receptor Potential Cation Channel Subfamily V Member 1
Chromosome17p13.2
Protein TypeProtein
FunctionTRPV1 is a capsaicin-activated ion channel that responds to heat and pain stimuli.
Primary Expressionsensory neurons (dorsal root ganglion, trigeminal ganglion), where it functions as a polymodal nociceptor activated by[@caterina2
PathwaysAutophagy
UniProt ID[Q9Y5Q1](https://www.uniprot.org/uniprotkb/Q9Y5Q1/entry)
GeneCardsTRPV1
Human Protein AtlasTRPV1
Associated DiseasesCancer, Ovarian Cancer
InteractionsTERT, GPX4, APOE4, TRPA1, FERROPTOSIS, TAUOPATHY
KG Connections231 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (9)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
LRP1-Dependent Tau Uptake Disruption
Score: 0.44

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (10)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
CFTR Gene
gene · KG edge: associated_with
casp3
gene · KG edge: regulates
CACNA1C Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

TRPV1 associated_with TRPV4
TRPV1 associated_with KCNN4
TRPV1 associated_with KCNQ1
TRPV1 associated_with CACNA1C
TRPV1 associated_with TRPM7
TRPV1 associated_with SCN5A
TRPV1 associated_with PIEZO1
TRPV1 associated_with KCNMA1
TRPV1 associated_with SCN1A
TRPV1 associated_with SCNN1A