gene 792 words KG: TYROBP 2026-03-24
kind:genesection:genesstate:published
Contents

TYROBP — TYRO Binding Protein (DAP12)

🧬 Gene Info
Gene SymbolTYROBP
Full NameTYRO Binding Protein (DAP12)
AliasesDAP12
Chromosome19q13.12
Protein TypeAdaptor Protein
Functionis a transmembrane signaling adaptor protein that plays critical roles in innate immunity and microglial function in the central nervous system.
Primary ExpressionMicroglia, Monocytes, NK cells, Osteoclasts
Molecular Weight12.1 kDa
Amino Acids113 aa
PathwaysInnate Immunity
UniProt IDQ9Y241
NCBI Gene ID7305
Ensembl IDENSG00000111653
OMIM605712
GeneCardsTYROBP
Human Protein AtlasTYROBP
Associated DiseasesALS, ALZHEIMER'S DISEASE, Aging, Alzheimer
Known Drugs/CompoundsBERBERINE
InteractionsRANK, OVERVIEW, TREM2, DAP12, APOE, SPI1
KG Connections383 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (20)

TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR
Score: 0.45
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.55

Related Analyses (11)

Does SYK activation provide neuroprotection or exacerbate ne
neurodegeneration · failed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
AIF1 Gene
gene · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates

Knowledge Graph (12 edges)

TYROBP provides_data_for ds-db4a006ea647
TYROBP activates RANK
TYROBP associated_with APP
TYROBP associated_with TREM2
TYROBP associated_with PSEN1
TYROBP associated_with CD33
TYROBP interacts_with OVERVIEW
TYROBP regulates RB1
TYROBP regulates TAU
TYROBP activates TREM2