| Gene Symbol | UNC5B |
| Full Name | Netrin-1 Receptor |
| Chromosome | 10q21.3 |
| Protein Type | Receptor |
| Function | is a member of the UNC-5 family of netrin-1 receptors that functions as a dependence receptor, mediating both attractive and repulsive axon guidance in the developing nervous system. |
| Molecular Weight | 105 kDa |
| Amino Acids | 945 aa |
| Exons | 21 |
| UniProt ID | [Q9NSP8](https://www.uniprot.org/uniprot/Q9NSP8) |
| Ensembl ID | ENSG00000144868 |
| GeneCards | UNC5B |
| Human Protein Atlas | UNC5B |
| UNC5B-long | The full-length receptor with all functional domains |
| UNC5B-short | Lacks portions of the intracellular domain, may act as a dominant-negative |
| Soluble variants | Secreted forms that may modulate netrin-1 signaling |
| Associated Diseases | AD, Aging, ALI, Als, ARDS, ARM |
| Interactions | APOE, APOPTOSIS, AXON, CANCER, INFLAMMATION, LDL |
| KG Connections | 54 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!