gene 1,577 words KG: WNT11 2026-03-26
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsonstopic:neurodevelopment
Contents

WNT11 Gene

🧬 Gene Info
Gene SymbolWNT11
AliasesWnt Family Member 11
FunctionLike all Wnt proteins, WNT11 contains several structural features essential for its function
Amino Acids354 aa
PathwaysWNT, Wnt, Wnt signaling, Wnt pathway
Ensembl IDENSG00000169718
GeneCardsWNT11
Human Protein AtlasWNT11
Wnt domain (residues 51-354)The conserved signaling domain containing multiple cysteine residues
Conserved cysteine patternTen conserved cysteine residues form disulfide bonds that stabilize the protein structure
Lipid modification sitePalmitoylation at a conserved cysteine is required for proper secretion and activity
Convergent extensionCell movements during gastrulation and neural tube closure
Tissue patterningEstablishing planar polarity in epithelial tissues
Axonal guidanceDirectional growth of axons during development
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsGRIN3B, TNFRSF1B, TNFRSF13C, HCRTR1, MYO7A, CHRM4
KG Connections41 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph