pathway 1,518 words KG: ent-gene-9f063e98 2026-03-31
section:mechanismskind:pathwaytopic:parkinsons
Contents

LRRK2-14-3-3 Interaction Network

🔬 Protein Info
Gene SymbolLRRK2
Full Name14-3-3 Interaction Network
Chromosome12q12
Protein TypeProtein
Subcellular Localization, kinase activity, and pathogenic signaling in Parkinson's disease (PD). The 14-3-3 prot
Amino Acids2527 aa
PathwaysMAPK
UniProt IDSearch UniProt
GeneCardsLRRK2
Human Protein AtlasLRRK2
Armadillo repeats (12-330)Protein-protein interactions
Ankyrin repeats (331-500)Additional interaction surfaces
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/CompoundsRAPAMYCIN, levodopa, Cigarette Smoking, MLi-2, PF-06447475, Environmental Toxicants
InteractionsATG16L1, RB1CC1, GABARAP, ERN1, STAT3, IFNG
KG Connections2480 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.45
Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.42
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.38

Related Analyses (30)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (25)

LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Ne
validation · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40
AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40
AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40
Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40

Knowledge Graph (2 edges)

ent-gene-9f063e98 data_in benchmark_ot_ad_answer_key:LRRK2
benchmark_ot_ad_answer_key:LRRK2 data_in ent-gene-9f063e98