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mechanism 1,990 words KG: TBP 2026-03-31
kind:mechanismsection:mechanismsstate:publishedevidence:strong
Contents

Polyglutamine Aggregation

⚙ Mechanism Info
NamePolyglutamine Aggregation
SummaryComprehensive mechanism of polyglutamine aggregation in Huntington's disease and related disorders
Key Genes/ProteinsRELA, RHEB, SPI1, HNF4A, AXIN1, MYC
Related DiseasesAls, Ms, Alzheimer

Knowledge Graph

Related Hypotheses (14)

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Score: 0.52Early Proteasome Restoration Therapy
Score: 0.50Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.42

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Knowledge Graph (12 edges)

TBP activates RELA
TBP activates RHEB
TBP activates SPI1
TBP activates HNF4A
TBP activates AXIN1
TBP activates MYC
TBP activates YWHAZ
TBP activates TXNIP
TBP activates EGR1
TBP activates STAT3
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