gene 1,363 words KG: TBP 2026-03-28
kind:genesection:genesstate:published
Contents

TBP - TATA-Box Binding Protein

🧬 Gene Info
Gene SymbolTBP
Full NameTATA-Box Binding Protein
Chromosome6q27
Protein TypeTranscription Factor
Functionis a general transcription factor essential for RNA polymerase II-mediated transcription initiation.
Amino Acids339 aa
Exons8
PathwaysAmyloid
UniProt IDP20226
NCBI Gene ID6908
Ensembl IDENSG00000112592
OMIM600075
GeneCardsTBP
Human Protein AtlasTBP
Chr Location6q27
Associated Diseasesneurodegeneration
InteractionsRELA, RHEB, SPI1, HNF4A, AXIN1, MYC
KG Connections56 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

See Also (13)

Packard Center for ALS Research
institution · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: regulates
HSP70 Inducer Therapies for Neurodegeneration
idea · KG edge: expressed_in
SPI1 Gene - PU.1
gene · KG edge: activates
SOCS3 - Suppressor of Cytokine Signaling 3
gene · KG edge: activates

Knowledge Graph (12 edges)

TBP activates RELA
TBP activates RHEB
TBP activates SPI1
TBP activates HNF4A
TBP activates AXIN1
TBP activates MYC
TBP activates YWHAZ
TBP activates TXNIP
TBP activates EGR1
TBP activates STAT3