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mechanism 3,933 words KG: mitophagy
Contents

mitophagy-defect

⚙ Mechanism Info
Namemitophagy
Key Genes/ProteinsADORA2A, AIF1, Alpha-Synuclein, ALZHEIMER, AMBRA1, AMPK
Related Diseasesaging, Alzheimer Disease, Alzheimer's disease, Alzheimer'S Disease
Related PathwaysAMPK/ULK1 pathway
Linked Hypotheses13 hypotheses

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🌐 Cross-references

Wikipedia

Related Hypotheses (3)

OPTN/TBK1 mutations create selective vulnerability by blocki
Score: 0.67TBK1 Loss Drives Motor Neuron Death Through Impaired Mitopha
Score: 0.53Astrocyte-specific autophagy deficiency induces NADPH oxidas
Score: 0.38

Knowledge Graph (12 edges)

AMPK activates mitophagy
CARM1 activates mitophagy
TFEB activates mitophagy
mitophagy inhibits mitochondrial_damage
CLU activates mitophagy
mitophagy activates oral_cancer
cisplatin activates mitophagy
GPR43 activates mitophagy
SQSTM1 regulates mitophagy
mitophagy protects_against neurodegenerative diseases

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