gene

ADORA2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ADORA2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

131Connections

1Hypotheses

1Analyses

50Outgoing

34Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ADORA2A
Full Name	Adenosine A2a Receptor
Chromosome	22q11.23
Protein Family	GPCR
Target Class	Gpcr
Function	encodes a 412-amino acid protein primarily expressed in the striatum, olfactory tubercle, and nucleus accumbens.
Mechanism of Action	Small molecule antagonists blocking adenosine A2A receptor signaling
Primary Expression	the striatum, olfactory tubercle, and nucleus accumbens
Druggability	Medium (0.57)
Clinical Stage	Approved
Pathways	Apoptosis, Mitophagy, Oxidative Stress
GeneCards	ADORA2A
Human Protein Atlas	ADORA2A
Associated Diseases	ALZHEIMER, als, ms, neurodegeneration
Known Drugs/Compounds	Istradefylline, Preladenant, CHEMBL3989695, CHEMBL3694769, CHEMBL3942498, CHEMBL197669
Interactions	BNIP3L, BCL2, DRP1, DNM1L, BNIP3, C1Q
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Adenosine-Astrocyte Metabolic Reset
KG Connections	129 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure: ADORA2A — PDB 4EIY Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ADORA2A["ADORA2A"] -->|"regulates"| ALS["ALS"]
    style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ADORA2A["ADORA2A"] -->|"interacts"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ADORA2A["ADORA2A"] -->|"regulates"| Aging["Aging"]
    style Aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ADORA2A["ADORA2A"] -->|"associated"| neurodegeneration["neurodegeneration"]
    style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ADORA2A["ADORA2A"] -->|"interacts"| BNIP3L["BNIP3L"]
    style BNIP3L fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ADORA2A["ADORA2A"] -->|"regulates"| Mitophagy["Mitophagy"]
    style Mitophagy fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    ADORA2A["ADORA2A"] -->|"regulates"| Apoptosis["Apoptosis"]
    style Apoptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    h_41bc2d38["h-41bc2d38"] -->|"targets"| ADORA2A["ADORA2A"]
    style h_41bc2d38 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"regulates"| ADORA2A["ADORA2A"]
    style MITOCHONDRIAL_DYSFUNCTION fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    AMBRA1["AMBRA1"] -->|"interacts"| ADORA2A["ADORA2A"]
    style AMBRA1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DRP1["DRP1"] -->|"interacts"| ADORA2A["ADORA2A"]
    style DRP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| ADORA2A["ADORA2A"]
    style APOPTOSIS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ADORA2A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (96)

Target	Relation	Type	Str
adenosine_metabolism	regulates	pathway	0.80
ALS	regulates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Aging	regulates	disease	0.65
neurodegeneration	associated_with	disease	0.65
neurodegeneration	implicated_in	disease	0.60
BNIP3L	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
BCL2	regulates	gene	0.60
AMBRA1	regulates	entity	0.60
BNIP3	regulates	entity	0.60
BNIP3L	regulates	entity	0.60
DNM1L	regulates	entity	0.60
DRP1	regulates	entity	0.60
DRP1	interacts_with	gene	0.60
OVERVIEW	regulates	gene	0.60
DNM1L	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
adenosine receptor	regulates	receptor	0.60
adenosine	regulates	neurotransmitter	0.60
AMBRA1	interacts_with	gene	0.60
adenosine receptor	interacts_with	receptor	0.60
adenosine	interacts_with	neurotransmitter	0.60
Mitophagy	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Autophagy	interacts_with	pathway	0.60
Oxidative Stress	regulates	pathway	0.60
AUTOPHAGY	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
RNA	regulates	gene	0.60
Alzheimer's disease	regulates	disease	0.60
RNA	interacts_with	gene	0.60
Alzheimer's disease	interacts_with	disease	0.60
NIX	regulates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.60
NIX	interacts_with	gene	0.60
ALZHEIMER	associated_with	disease	0.60
neurodegeneration	promoted: Adenosine-Astrocyte Metabolic Reset	disease	0.56
C1Q	activates	gene	0.55
phagocytosis	activates	process	0.55
purinergic signaling	participates_in	pathway	0.55
neurodegeneration	regulates	disease	0.55
insulin signaling	participates_in	pathway	0.55
neurodegeneration	inhibits	disease	0.55
complement cascade	participates_in	pathway	0.55

Incoming (35)

Source	Relation	Type	Str
h-41bc2d38	targets_gene	hypothesis	0.90
h-41bc2d38	targets	hypothesis	0.80
AMBRA1	interacts_with	gene	0.60
DRP1	interacts_with	gene	0.60
BNIP3	interacts_with	gene	0.60
OVERVIEW	regulates	gene	0.60
BCL2	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
NIX	interacts_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
AGING	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
BMAL1	co_discussed	gene	0.40
HCRTR2	co_discussed	gene	0.40
CLOCK	co_discussed	gene	0.40
BDNF	co_discussed	gene	0.40
AQP4	co_discussed	gene	0.40
MTNR1A	co_discussed	gene	0.40
CX3CR1	co_discussed	gene	0.40
HCRT	co_discussed	gene	0.40
CACNA1G	co_discussed	gene	0.40
ADRA2A	co_discussed	gene	0.40
TFEB	co_discussed	gene	0.40
A2A Adenosine Receptor Protein	references	protein	0.40
HDAC	co_discussed	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Adenosine-Astrocyte Metabolic Reset	0.557	neurodegeneration	Sleep disruption as cause and consequenc

Mentioning Analyses (1)

Scientific analyses that reference this entity

Sleep disruption as cause and consequence of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.557

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell re [PMID:31488706]	Packer JS, Zhu Q, Huynh C, Sivaramakrish	Science	2019	1
Metabolic asymmetry and the global diversity of marine predators. [PMID:30679341]	Grady JM, Maitner BS, Winter AS, Kaschne	Science	2019	1
A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)? [PMID:28224793]	Wang Z, DeWitt JC, Higgins CP, Cousins I	Environ Sci Technol	2017	1
Gene Expression by Mouse Inner Ear Hair Cells during Development. [PMID:25904789]	Scheffer DI, Shen J, Corey DP, Chen ZY	J Neurosci	2015	1
Chapter 6: Structural variation and medical genomics. [PMID:23300412]	Raphael BJ	PLoS Comput Biol	2012	1
Caffeine and adenosine. [PMID:20164566]	Ribeiro JA, Sebastião AM	J Alzheimers Dis	2010	1
De novo purine synthesis reprograms the macrophage inflammatory response and the [PMID:41756441]	Haskó G, Liu L, Németh ZH, Wagener G, Ak	Research square	2026	0
Parthenolide inhibits methamphetamine-induced depressive-like behavior by target [PMID:41795299]	Hui R, Feng T, Hou C, Xu J, Zhang R, Ji	Phytomedicine : international	2026	0
Adenosine 2A receptor-dependent activation of AMPK represses TH17 cell pathogeni [PMID:40986641]	Papadopoulou G, Valakos D, Polydouri I,	Science signaling	2025	0
Surface d-Band Modulation via Biodirected Mineralization Enables Nanoenzymes to [PMID:41073355]	Li X, Zhao Q, Feng X, Cui P, Yu J, Liang	ACS nano	2025	0
Endothelial adenosine receptor 2A loss alleviates diabetic vascular calcificatio [PMID:41067595]	Zhou Y, Zhao D, Ma Q, Xu J, Cai Y, Yang	Pharmacological research	2025	0
Targeting adenosine 2A receptor signaling suppresses vascular calcification by r [PMID:41201506]	Zhou Y, Zhao D, Ma Q, Lee S, Roh K, Cai	Pharmacological research	2025	0
Transcriptional control of pancreatic cancer immunosuppression by metabolic enzy [PMID:37291128]	Tang T, Huang X, Lu M, Zhang G, Han X, L	Nature communications	2023	0
Intestinal microbiota: A potential target for enhancing the antitumor efficacy a [PMID:33845122]	["Luo B", "Zhang Y", "Zhang C", "Liu X",	Cancer letters	2021	0
Sepsis expands a CD39+ plasmablast population that promotes immunosuppression vi [PMID:34473957]	Nascimento DC, Viacava PR, Ferreira RG,	Immunity	2021	0
The integration of pharmacophore-based 3D QSAR modeling and virtual screening in [PMID:30605479]	["Fan F", "Toledo Warshaviak D", "Hamade	PloS one	2019	0
Pharmacogenetics and induction/consolidation therapy toxicities in acute lymphob [PMID:26644204]	["Franca R", "Rebora P", "Bertorello N",	The pharmacogenomics journal	2017	0
Cord blood gene expression supports that prenatal exposure to perfluoroalkyl sub [PMID:25812627]	["Pennings J", "Jennen D", "Nygaard U",	Journal of immunotoxicology	2016	0
Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Simil [PMID:9160173]	["Lennern\u00e4s H", "Fager G"]	Clinical pharmacokinetics	1997	0

ADORA2A

Understanding Entity Pages

Wiki Pages (20)

Section 99: Purinergic Signaling and P2X/P2Y Receptors in CBS/PSP

ADCY3 — Adenylate Cyclase 3

IL27 — Interleukin 27

Autophagy Enhancement for Tauopathy

Adenosine Signaling in Neurodegeneration

Purinergic Signaling in Parkinson's Disease

Striatal Medium Spiny Neurons in Neurodegenerative Disease

G-Protein Coupled Receptor Signaling in Parkinson's Disease

Autophagy Enhancers for PD

Purinergic Signaling Dysfunction Hypothesis in Parkinson's Disease

Adenosine A2A Receptor Antagonist Therapy

ADCY5 Gene

Adenosine A2A Receptor Neurons

Adenosine A1/A3 Receptor Modulator Therapy

Istradefylline (Nourianz)

Microglia Modulation Therapies

G Proteins

GNAL — Gαolf Subunit

Nucleus Accumbens D2 Medium Spiny Neurons (Expanded)