gene 2,167 words KG: NOTCH2 2026-03-27
kind:genesection:genesstate:published
Contents

NOTCH2 — Notch Receptor 2

🧬 Gene Info
Gene SymbolNOTCH2
Full NameNotch Receptor 2
Chromosome1p11
Protein TypeReceptor
Functionencodes a highly conserved transmembrane protein that serves as a critical regulator of cell fate decisions, tissue homeostasis, and developmental processes throughout the nervous and vascular syst...
Primary ExpressionCerebral cortex, Hippocampus, Vascular smooth muscle
Molecular Weight265 kDa
PathwaysPathway: An Overview, NOTCH, Notch, Notch Signaling
UniProt IDQ12983
NCBI Gene ID4853
Ensembl IDENSG00000134250
OMIM600275
GeneCardsNOTCH2
Human Protein AtlasNOTCH2
Associated DiseasesDiabetes, Glioblastoma
InteractionsLRP1, DLL4, NFKBIE, CDKN2A, SMARCA4, GJA1
KG Connections212 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Knowledge Graph (12 edges)

NOTCH2 inhibits LRP1
NOTCH2 inhibits DLL4
NOTCH2 therapeutic_target EP300
NOTCH2 therapeutic_target CTNNB1
NOTCH2 therapeutic_target NEUROD1
NOTCH2 therapeutic_target MYC
NOTCH2 therapeutic_target VEGFA
NOTCH2 therapeutic_target ABCB1
NOTCH2 therapeutic_target FOXM1
NOTCH2 therapeutic_target LEF1