gene 696 words KG: BRG1 2026-03-24
kind:genesection:genesstate:published
Contents

BRG1 Gene

🧬 Gene Info
Gene SymbolBRG1 (SMARCA4)
Full NameSWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin
Chromosome19q13.2
FunctionSMARCA4 encodes the central ATPase of the SWI/SNF complex.
Primary Expressionneural progenitors, increases with differentiation
Molecular Weight185 kDa
PathwaysEpigenetic
UniProt IDP51532
NCBI Gene ID6597
Ensembl IDENSG00000127616
OMIM603254
Associated DiseasesCancer, Colorectal Cancer, Inflammatory Bowel Disease, Tumor
Known Drugs/Compoundsrapamycin
InteractionsAKT, ERN1, LC3, MELK, MTOR, NOD2
KG Connections229 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.48
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.45
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.41
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.38
CYP46A1 Overexpression Gene Therapy
Score: 0.63

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: expressed_in
BECN1 Gene
gene · KG edge: associated_with
BECN1 Gene
gene · KG edge: activates
AXIN2 Gene
gene · KG edge: regulates
AXIN1 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

BRG1 therapeutic_target NRCAM
BRG1 therapeutic_target NOTCH2
BRG1 regulates EP300
BRG1 regulates CTNNB1
BRG1 therapeutic_target NEUROD1
BRG1 therapeutic_target MYC
BRG1 therapeutic_target VEGFA
BRG1 therapeutic_target ABCB1
BRG1 regulates FOXM1
BRG1 therapeutic_target LEF1