Contents

PPARGC1A Gene

🧬 Gene Info

Gene Symbol	PPARGC1A
Full Name	PPARG Coactivator 1 Alpha
Chromosome	4p15.31
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	PPARGC1A encodes PGC-1α (PPAR gamma coactivator 1-alpha), a transcriptional coactivator that serves as a master regulator of mitochondrial biogenesis and cellular energy metabolism.
Mechanism of Action	Small molecule modulator of transcriptional coactivator function
Primary Expression	tissues with high metabolic demand: - Brain: Neurons (especially in substantia nigra, hippocampus), [astrocytes](/entities/as
Druggability	Low (0.43)
Clinical Stage	Approved
Pathways	Apoptosis, Autophagy, Cell Cycle, Er Stress, Ferroptosis
UniProt ID	Q9UBK2
NCBI Gene ID	10891
Ensembl ID	ENSG00000109819
OMIM	604517
GeneCards	PPARGC1A
Human Protein Atlas	PPARGC1A
Associated Diseases	Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia, athletic_performance
Known Drugs/Compounds	Aloe-emodin, glitazones, Kaixinsan, Lactiplantibacillus plantarum SG5, metformin, METFORMIN
Interactions	AKT1, ALS, AMPK, amyloid beta, amyloid-beta, amyotrophic lateral sclerosis
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Perforant Path Presynaptic Terminal Protection Str PGC1α Activation in PV+ Interneurons Bypasses Mito
KG Connections	983 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph