gene 1,824 words KG: PRNP 2026-03-29
kind:genesection:genesstate:publishedtopic:prion-diseasetopic:alzheimers
Contents

PRNP — Prion Protein

🧬 Gene Info
Gene SymbolPRNP
Full NamePrion Protein (Kanno Blood Group)
Chromosome20p13
Functionis a gene located on chromosome 20p13 that encodes the major prion protein (PrP), a glycosylphosphatidylinositol (GPI)-anchored glycoprotein of 253 amino acids[@genetic2003].
Primary ExpressionCerebral cortex, Cerebellum, Hippocampus, Thalamus, Basal ganglia, Brainstem
Amino Acids253 aa
PathwaysAmyloid
UniProt IDP04156
NCBI Gene ID5621
Ensembl IDENSG00000171867
OMIM176640
GeneCardsPRNP
Human Protein AtlasPRNP
Associated DiseasesALS, Aging, Alzheimer, Creutzfeldt-Jakob, Prion Disease
InteractionsIL1A, SORL1, BACE1, SNCA, TH, Prion
KG Connections112 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Knowledge Graph (12 edges)

PRNP associated_with Creutzfeldt-Jakob
PRNP associated_with IDE
PRNP associated_with TGFB1
PRNP associated_with BACE1
PRNP associated_with HSPG2
PRNP associated_with IL10
PRNP associated_with ACE
PRNP associated_with SORL1
PRNP associated_with BDNF
PRNP associated_with MAPT