Contents

prkaca Gene

🧬 Gene Info

Gene Symbol	PRKACA
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	40.6 kDa
Pathways	mTOR, mtor
GeneCards	PRKACA
Human Protein Atlas	PRKACA
Serine/threonine kinase	Phosphorylates serine and threonine residues
cAMP-dependent	Activity requires binding of cAMP to regulatory subunits
Heterotetrameric complex	R2C2 (2 regulatory + 2 catalytic subunits)
Substrate specificity	Broad substrate range including transcription factors, ion channels, and metabolic enzymes
Catalytic domain	Kinase domain in the C-terminal region
Nuclear localization	Can translocate to nucleus to phosphorylate transcription factors
Isoforms	Multiple catalytic subunit isoforms (Cα, Cβ, Cγ)
Autophosphorylation	Regulatory serine residues
Brain	High expression in hippocampus, cortex, cerebellum
Associated Diseases	Infection, Inflammation, Sepsis
Interactions	Actin, CAV1, CAVEOLIN-1, CPT1A, Ras, Ubiquitin
KG Connections	83 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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Knowledge Graph

PI3K therapeutic_target PRKACA

RELA therapeutic_target PRKACA

PTGS2 therapeutic_target PRKACA

PRKACA therapeutic_target AKT1

PRKACA therapeutic_target TNF

PRKACA therapeutic_target RAF1

PRKACA therapeutic_target CHUK

PRKACA therapeutic_target JUN

HTRA2 associated_with PRKACA

AIM2 associated_with PRKACA