| Gene Symbol | BDNF |
| Full Name | Brain-Derived Neurotrophic Factor |
| Chromosome | 11p14.1 |
| Protein Family | Neurotrophin family |
| Protein Type | Ligand |
| Target Class | Ligand |
| Function | Protein replacement therapy or small molecule mimetic |
| Mechanism of Action | Protein replacement therapy or small molecule mimetic |
| Primary Expression | Secreted, Synaptic vesicles |
| Subcellular Localization | Secreted, Synaptic vesicles |
| Druggability | Low (0.29) |
| Clinical Stage | Phase II |
| Pathways | Akt, Apoptosis, Autophagy, Cell Cycle, Cholesterol |
| UniProt ID | P23560 |
| NCBI Gene ID | 627 |
| Ensembl ID | ENSG00000176697 |
| OMIM | 113505 |
| GeneCards | BDNF |
| Human Protein Atlas | BDNF |
| Associated Diseases | ADHD, ALS, ANXIETY, Addiction, Aging |
| Known Drugs/Compounds | RAPAMYCIN, CURCUMIN, METFORMIN, KETAMINE, ANTIDEPRESSANTS, curcumin |
| Interactions | CHR2, GLP1R, IL18BP, CALCA, GDNF, SYN3 |
| SciDEX Target | View Target Profile (4 clinical trials) |
| SciDEX Hypotheses | Hippocampal CA3-CA1 synaptic rescue via DHHC2-medi Hippocampal CA3-CA1 circuit rescue via neurogenesi Neuroplasticity-Enhanced Learning Hypothesis |
| KG Connections | 4734 knowledge graph edges |
| Databases | GeneCardsHPASTRING |