protein 1,238 words KG: CSF1R 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

CSF1R Protein (Colony Stimulating Factor 1 Receptor)

🔬 Protein Info
Gene SymbolCSF1R
Full NameColony Stimulating Factor 1 Receptor
Chromosome5q32
Protein TypeReceptor
FunctionUpon ligand binding, CSF1R undergoes
Primary ExpressionMicroglia, Macrophages, Osteoclasts, Placenta
Molecular Weight107.6 kDa
Amino Acids972 aa
PathwaysPI3K
UniProt IDP07333
NCBI Gene ID1436
Ensembl IDENSG00000182578
OMIM164770
GeneCardsCSF1R
Human Protein AtlasCSF1R
Associated DiseasesALS, Alzheimer, Anxiety, Atherosclerosis, CSF1R-related Leukoencephalopathy
Known Drugs/CompoundsKETAMINE, NICOTINAMIDE, nicotinamide, dasatinib, PLX3397, PLX5622
InteractionsSTAT5, MECP2, JAK2, PDGFRB, BDNF, CX3CR1
KG Connections586 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

TREM2-CSF1R Cross-Talk in Microglial Metabolic Reprogramming
Score: 0.59
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.48
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.62

Related Analyses (25)

Neuroinflammation and microglial priming in early Alzheimer'
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (4)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
FTD Microglia Role: Protective vs Destructive Mechanism Stud
validation · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.40

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
AIF1 Gene
gene · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates

Knowledge Graph (12 edges)

CSF1R activates IL7R
CSF1R activates NTRK3
CSF1R activates PTK2B
CSF1R activates TYK2
CSF1R phosphorylates JAK2
CSF1R phosphorylates PDGFRB
CSF1R expressed_in JAK2
CSF1R expressed_in NTRK3
CSF1R expressed_in PDGFRB
CSF1R co_discussed CYTOKINE