protein 1,590 words KG: DJ1 2026-03-28
kind:proteinsection:proteinsstate:publishedparkinsonoxidative-stressmitochondrial-function
Contents

DJ-1 Protein

🔬 Protein Info
Gene SymbolDJ
Full Name1 Protein
AliasesDJ1
Protein FamilyDJ-1 family, ThiJ/PfpI superfamily
FunctionDj 1 Protein (Park7) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Subcellular LocalizationCytosol, nucleus, mitochondria
Molecular Weight~20 kDa (189 amino acids)
UniProt IDQ99497
GeneCardsDJ
Human Protein AtlasDJ
Protein NameProtein DJ-1
GenePARK7
PDB IDs1PDV, 1X4X, 2MO3, 5D8J
Disease AssociationAutosomal recessive early-onset Parkinson's disease (PARK7)
Associated DiseasesInflammation, Neuroinflammation, PARKINSON'S DISEASE, Parkinson
Known Drugs/Compoundslevodopa
InteractionsSTING, NRF2, DNAJC6, FBXO7, GBA1, LRRK2
KG Connections106 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40

See Also (7)

LRRK2 G2019S Transgenic Mouse Model
model · KG edge: associated_with
NRF2 Activator Therapy
idea · KG edge: activates
Genes
index · KG edge: associated_with
Parkin (PARK2)
entity · KG edge: causes
Neuroinflammation PET Imaging in CBS/PSP
diagnostic · KG edge: contributes_to

Knowledge Graph (12 edges)

DJ1 associated_with PINK1
DJ1 associated_with LRRK2
DJ1 associated_with VPS35
DJ1 causes PARKIN
DJ1 causes LRRK2
DJ1 activates STING
DJ1 activates NRF2
DJ1 involved_in Neuronal Survival
DJ1 associated_with PARKIN
DJ1 causes VPS35