Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DNAJC6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DNAJC6 |
| Full Name | DnaJ Heat Shock Protein Family (Hsp40) Member C6 |
| Aliases | Auxilin-1, Auxilin |
| Chromosome | 19q13.43 |
| Protein Type | Chaperone |
| Function | Unlike its close relative DNAJC5 (cystinosin), DNAJC6/Auxilin-2 is specifically expressed in neuronal tissues and regulates clathrin-mediated endocytosis[@roosen2014]. |
| Primary Expression | neurons throughout the brain, with particularly high levels in the substantia nigra, basal ganglia, and cerebral [cortex](/brain- |
| Molecular Weight | 70 kDa |
| Amino Acids | 935 aa |
| Exons | 15 |
| Pathways | Oxidative Stress |
| NCBI Gene ID | 9829 |
| Ensembl ID | ENSG00000138193 |
| GeneCards | DNAJC6 |
| Human Protein Atlas | DNAJC6 |
| Associated Diseases | Als, Alzheimer, Huntington, Ms, Parkinson, Parkinson's disease |
| Interactions | FBXO7, PINK1, PLA2G6, PRKN, SYNJ1, VPS13C |
| KG Connections | 137 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
DNAJC6["<b>DNAJC6</b>"]
Obesity{"Obesity"}
DNAJC6 -->|"regulates"| Obesity
Ms{"Ms"}
DNAJC6 -->|"inhibits"| Ms
Parkinson{"Parkinson"}
DNAJC6 -->|"associated with"| Parkinson
Als{"Als"}
DNAJC6 -->|"associated with"| Als
DNAJC6 -->|"associated with"| Ms
DNAJC6 -->|"therapeutic target"| Als
Aging{"Aging"}
DNAJC6 -->|"therapeutic target"| Aging
LC3["LC3"]
DNAJC6 -->|"expressed in"| LC3
Autophagy(["Autophagy"])
DNAJC6 -->|"expressed in"| Autophagy
Insulin_Signaling(["Insulin Signaling"])
DNAJC6 -->|"inhibits"| Insulin_Signaling
Mitochondrial_Function(["Mitochondrial Function"])
DNAJC6 -->|"inhibits"| Mitochondrial_Function
Mtor(["Mtor"])
DNAJC6 -->|"expressed in"| Mtor
MTOR["MTOR"]
MTOR -->|"expressed in"| DNAJC6
GLUT4["GLUT4"]
GLUT4 -->|"inhibits"| DNAJC6
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"expressed in"| DNAJC6
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"associated with"| DNAJC6
ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
ALPHA_SYNUCLEIN -->|"associated with"| DNAJC6
PARKIN["PARKIN"]
PARKIN -->|"associated with"| DNAJC6
LRRK2["LRRK2"]
LRRK2 -->|"associated with"| DNAJC6
INPP5F["INPP5F"]
INPP5F -->|"associated with"| DNAJC6
GAK["GAK"]
GAK -->|"associated with"| DNAJC6
SYNJ1["SYNJ1"]
SYNJ1 -->|"associated with"| DNAJC6
AUTOPHAGY -->|"associated with"| DNAJC6
AGING["AGING"]
AGING -->|"therapeutic target"| DNAJC6
style DNAJC6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| FBXO7 | interacts_with | gene | 0.80 |
| PINK1 | interacts_with | gene | 0.80 |
| PRKN | interacts_with | gene | 0.80 |
| SYNJ1 | interacts_with | gene | 0.80 |
| VPS13C | interacts_with | gene | 0.70 |
| GBA1 | interacts_with | gene | 0.70 |
| LRRK2 | interacts_with | gene | 0.70 |
| PARK7 | interacts_with | gene | 0.70 |
| SNCA | interacts_with | gene | 0.70 |
| neurons | expressed_in | cell_type | 0.70 |
| Obesity | regulates | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Huntington | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Ataxia | regulates | disease | 0.65 |
| Spinocerebellar Ataxia | regulates | disease | 0.65 |
| ALS | protects_against | disease | 0.65 |
| Parkinson | protects_against | disease | 0.65 |
| LC3 | expressed_in | gene | 0.60 |
| PARK2 | associated_with | gene | 0.60 |
| VPS35 | associated_with | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| SYNJ1 | associated_with | gene | 0.60 |
| ROCK2 | regulates | gene | 0.60 |
| ATP13A2 | associated_with | gene | 0.60 |
| PLA2G6 | associated_with | gene | 0.60 |
| ATP1A3 | associated_with | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| CALB2 | regulates | gene | 0.60 |
| DNAJC5 | regulates | gene | 0.60 |
| Rb | regulates | protein | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| CAT | protects_against | gene | 0.60 |
| LRRK2 | regulates | gene | 0.60 |
| PLA2G6 | interacts_with | gene | 0.60 |
| VPS35 | interacts_with | gene | 0.60 |
| FBXO7 | associated_with | gene | 0.60 |
| PARK7 | associated_with | gene | 0.60 |
| FBXO7 | expressed_in | gene | 0.60 |
| GBA1 | expressed_in | gene | 0.60 |
| LRRK2 | expressed_in | gene | 0.60 |
| PINK1 | expressed_in | gene | 0.60 |
| PRKN | expressed_in | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ATP13A2 | interacts_with | gene | 0.80 |
| MTOR | expressed_in | gene | 0.60 |
| PARKIN | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| GAK | associated_with | gene | 0.60 |
| SYNJ1 | associated_with | gene | 0.60 |
| CALB2 | regulates | gene | 0.60 |
| GCH1 | associated_with | gene | 0.60 |
| VPS35 | associated_with | gene | 0.60 |
| GBA1 | associated_with | gene | 0.60 |
| TARDBP | associated_with | gene | 0.60 |
| PARK7 | associated_with | gene | 0.60 |
| DNAJC13 | associated_with | gene | 0.60 |
| FBXO7 | associated_with | gene | 0.60 |
| PINK1 | associated_with | gene | 0.60 |
| VPS13C | associated_with | gene | 0.60 |
| ROCK2 | regulates | gene | 0.60 |
| VPS35 | regulates | gene | 0.60 |
| UCHL1 | regulates | gene | 0.60 |
| ATP13A2 | associated_with | gene | 0.60 |
| DJ1 | interacts_with | gene | 0.60 |
| ATP13A2 | expressed_in | gene | 0.60 |
| DJ1 | expressed_in | gene | 0.60 |
| ATP1A3 | associated_with | gene | 0.60 |
| GLUT4 | inhibits | gene | 0.60 |
| AUTOPHAGY | expressed_in | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| ALPHA-SYNUCLEIN | associated_with | gene | 0.60 |
| INPP5F | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| AGING | therapeutic_target | gene | 0.60 |
| FLAVONOIDS | therapeutic_target | gene | 0.60 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 0.60 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.60 |
| LYSOSOME | therapeutic_target | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| HUNTINGTON | regulates | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| SYNAPSE | associated_with | gene | 0.60 |
| CALB2 | co_expressed_with | gene | 0.50 |
| DNAJC5 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||