gene

DNAJC6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJC6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

137Connections
0Hypotheses
0Analyses
50Outgoing
41Incoming

Summary

Page for DNAJC6 — DnaJ Heat Shock Protein Family Member A6

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🧬 Gene Info
Gene SymbolDNAJC6
Full NameDnaJ Heat Shock Protein Family (Hsp40) Member C6
AliasesAuxilin-1, Auxilin
Chromosome19q13.43
Protein TypeChaperone
FunctionUnlike its close relative DNAJC5 (cystinosin), DNAJC6/Auxilin-2 is specifically expressed in neuronal tissues and regulates clathrin-mediated endocytosis[@roosen2014].
Primary Expressionneurons throughout the brain, with particularly high levels in the substantia nigra, basal ganglia, and cerebral [cortex](/brain-
Molecular Weight70 kDa
Amino Acids935 aa
Exons15
PathwaysOxidative Stress
NCBI Gene ID9829
Ensembl IDENSG00000138193
GeneCardsDNAJC6
Human Protein AtlasDNAJC6
Associated DiseasesAls, Alzheimer, Huntington, Ms, Parkinson, Parkinson's disease
InteractionsFBXO7, PINK1, PLA2G6, PRKN, SYNJ1, VPS13C
KG Connections137 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

DNAJC6 — DnaJ Heat Shock Protein Family Member A6

gene · 873 words

Synaptic Vesicle Trafficking in Parkinson's Disease

mechanism · 4417 words

proteasome-ubiquitin-system-dysfunction-parkinsons

general · 3977 words

DNAJC13 — DnaJ Heat Shock Protein Family Member C13

gene · 3528 words

AP2M1 Gene

gene · 3193 words

Diseases

index · 3070 words

Pathway Diagram

graph TD
    DNAJC6["<b>DNAJC6</b>"]
    Obesity{"Obesity"}
    DNAJC6 -->|"regulates"| Obesity
    Ms{"Ms"}
    DNAJC6 -->|"inhibits"| Ms
    Parkinson{"Parkinson"}
    DNAJC6 -->|"associated with"| Parkinson
    Als{"Als"}
    DNAJC6 -->|"associated with"| Als
    DNAJC6 -->|"associated with"| Ms
    DNAJC6 -->|"therapeutic target"| Als
    Aging{"Aging"}
    DNAJC6 -->|"therapeutic target"| Aging
    LC3["LC3"]
    DNAJC6 -->|"expressed in"| LC3
    Autophagy(["Autophagy"])
    DNAJC6 -->|"expressed in"| Autophagy
    Insulin_Signaling(["Insulin Signaling"])
    DNAJC6 -->|"inhibits"| Insulin_Signaling
    Mitochondrial_Function(["Mitochondrial Function"])
    DNAJC6 -->|"inhibits"| Mitochondrial_Function
    Mtor(["Mtor"])
    DNAJC6 -->|"expressed in"| Mtor
    MTOR["MTOR"]
    MTOR -->|"expressed in"| DNAJC6
    GLUT4["GLUT4"]
    GLUT4 -->|"inhibits"| DNAJC6
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"expressed in"| DNAJC6
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| DNAJC6
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"associated with"| DNAJC6
    PARKIN["PARKIN"]
    PARKIN -->|"associated with"| DNAJC6
    LRRK2["LRRK2"]
    LRRK2 -->|"associated with"| DNAJC6
    INPP5F["INPP5F"]
    INPP5F -->|"associated with"| DNAJC6
    GAK["GAK"]
    GAK -->|"associated with"| DNAJC6
    SYNJ1["SYNJ1"]
    SYNJ1 -->|"associated with"| DNAJC6
    AUTOPHAGY -->|"associated with"| DNAJC6
    AGING["AGING"]
    AGING -->|"therapeutic target"| DNAJC6
    style DNAJC6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (96)

TargetRelationTypeStr
FBXO7interacts_withgene0.80
PINK1interacts_withgene0.80
PRKNinteracts_withgene0.80
SYNJ1interacts_withgene0.80
VPS13Cinteracts_withgene0.70

Incoming (41)

SourceRelationTypeStr
ATP13A2interacts_withgene0.80
MTORexpressed_ingene0.60
PARKINassociated_withgene0.60
LRRK2associated_withgene0.60
GAKassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found