protein 1,550 words KG: ERK2 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

ERK2 Protein

🔬 Protein Info
Gene SymbolMAPK1
Full NameMitogen-Activated Protein Kinase 1
AliasesERK2
Chromosome22q11.22
Protein TypeKinase
Functionis a serine/threonine protein kinase that serves as a central mediator of intracellular signal transduction.
Subcellular Localization</th><td>Cytoplasm, nucleus</td></tr> [@roskoski2012]
Molecular Weight42 kDa
Amino Acids360 aa
PathwaysMAPK, Mapk, MAPK signaling
UniProt IDP28482
NCBI Gene ID5594
Ensembl IDENSG00000100030
GeneCardsMAPK1
Human Protein AtlasMAPK1
Associated DiseasesAging, Als, Cancer, Carcinoma, Heart Failure, Melanoma
InteractionsDRP1, ATF4, TFAM, BCL2, BAX, ERK1
KG Connections172 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (11)

Alzheimer Indonesia
institution · KG edge: activates
DUSP6 — Dual Specificity Phosphatase 6 (MKP3)
gene · KG edge: activates
DUSP1 Gene
gene · KG edge: activates
DRP1 Gene - Dynamin 1-Like Protein
gene · KG edge: activates
CYLD Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ERK2 activates DRP1
ERK2 activates ATF4
ERK2 activates TFAM
ERK2 activates BCL2
ERK2 activates BAX
ERK2 activates ERK1
ERK2 regulates ERK1
ERK2 activates CHOP
ERK2 activates MIRO1
ERK2 phosphorylates DRP1