gene 949 words KG: ERK2 2026-03-24
kind:genesection:genesstate:published
Contents

ERK2 (MAPK1)

🧬 Gene Info
Gene SymbolMAPK1
Full NameMitogen-Activated Protein Kinase 1
AliasesERK2, p42 MAPK, PRKM1
Chromosome22q11.22
Protein FamilyMAP kinase family, CMGC group
Protein TypeKinase
Functionis a protein involved in various cellular processes relevant to neurodegeneration.
Subcellular LocalizationCytoplasm, nucleus
Molecular Weight41 kDa
Amino Acids360 aa
PathwaysMAPK, Mapk, MAPK signaling, MAPK pathway
UniProt IDP28482
NCBI Gene ID5594
Ensembl IDENSG00000100030
GeneCardsMAPK1
Human Protein AtlasMAPK1
Associated DiseasesALS, Aging, Alzheimer, Cancer, Carcinoma
Known Drugs/CompoundsZuojin Pill, Chrysotoxine, DEP, DMP, DOP
InteractionsMAP1LC3B, MTOR, TLR4, LC3, TFEB, AKT
KG Connections948 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Mitochondrial Transfer Pathway Enhancement
Score: 0.44

Related Analyses (4)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (7)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Mechanism: Progranulin Loss and TDP-43 Pathology in FTD
validation · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
DUSP6 — Dual Specificity Phosphatase 6 (MKP3)
gene · KG edge: activates
DUSP1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

ERK2 activates DRP1
ERK2 activates ATF4
ERK2 activates TFAM
ERK2 activates BCL2
ERK2 activates BAX
ERK2 activates ERK1
ERK2 regulates ERK1
ERK2 activates CHOP
ERK2 activates MIRO1
ERK2 phosphorylates DRP1