protein 615 words KG: MYD88 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

MyD88 Adapter Protein

🔬 Protein Info
Gene SymbolMYD88
AliasesMyeloid Differentiation Primary Response 88
Protein FamilyMyD88 adaptor proteins
Protein TypeAdaptor Protein
FunctionMyD88 is an adaptor protein essential for signaling from most Toll-like receptors (TLRs) and IL-1R family members.
Molecular Weight33 kDa
PathwaysNF-κB, MAPK pathway, MAPK
UniProt ID[Q99836](https://www.uniprot.org/uniprot/Q99836)
GeneCardsMYD88
Human Protein AtlasMYD88
Associated DiseasesEncephalitis, Inflammation, Ischemia, Lymphoma, Ms, Multiple Sclerosis
InteractionsTLR4, TLR9, NLRP3, TREM2, POLE, GSDMD
KG Connections729 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (27)

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Circadian Clock-Autophagy Synchronization
Score: 0.55

Related Analyses (15)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (3)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: activates
Amyotrophic Lateral Sclerosis
redirect · KG edge: regulates

Knowledge Graph (12 edges)

MYD88 treats TLR4
MYD88 treats TREM2
MYD88 activates NRF2
MYD88 activates PI3K
MYD88 activates PUMA
MYD88 activates SIGMAR1
MYD88 activates TAAR1
MYD88 activates VEGF
MYD88 activates TLR4
MYD88 associated_with PUMA