protein 615 words KG: MYD88
Contents

MyD88 Adapter Protein

🔬 Protein Info
Gene SymbolMYD88
AliasesMyeloid Differentiation Primary Response 88
Protein FamilyMyD88 adaptor proteins
Protein TypeAdaptor Protein
FunctionMyD88 is an adaptor protein essential for signaling from most Toll-like receptors (TLRs) and IL-1R family members.
Molecular Weight33 kDa
PathwaysNF-κB, MAPK pathway, MAPK
UniProt ID[Q99836](https://www.uniprot.org/uniprot/Q99836)
GeneCardsMYD88
Human Protein AtlasMYD88
Associated DiseasesEncephalitis, Inflammation, Ischemia, Lymphoma, Ms, Multiple Sclerosis
InteractionsACOD1, AKT, AKT1, Albumin, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections719 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (27)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
Aquaporin-4 Polarization Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Extracellular Matrix Stiffness Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Vagal Afferent Microbial Signal Modulation
Score: 0.62
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Related Analyses (14)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (3)

Amyotrophic Lateral Sclerosis
redirect · KG edge: regulates
Alzheimer Indonesia
institution · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates

Knowledge Graph (12 edges)

FIS1 associated_with MYD88
TLR9 activates MYD88
MYD88 activates TLR4
POLE activates MYD88
TREM2 activates MYD88
NLRP3 activates MYD88
TLR4 activates MYD88
GSDMD activates MYD88
VEGF associated_with MYD88
BAX associated_with MYD88

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