protein 524 words KG: PI3KPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

PI3K Protein

🔬 Protein Info
Gene SymbolPI3K
Full NamePhosphoinositide 3-Kinase
AliasesPhosphatidylinositol 3-kinase, VPS34
ChromosomeVarious (multiple genes across classes)
Protein FamilyPI3K family, lipid kinases
Protein TypeKinase
FunctionClass I PI3Ks: Generate PIP3 from PIP2 - Activated by receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCRs), and small GTPases (Ras) - p110α (PIK3CA): growth factor signaling
Subcellular LocalizationPlasma membrane, cytoplasm
PathwaysAUTOPHAGY, LIPID METABOLISM, OXIDATIVE_STRESS, PI3K/AKT, PI3K_AKT_MTOR_pathway
UniProt IDP42336 (p110α)
NCBI Gene ID5290
GeneCardsPI3K
Human Protein AtlasPI3K
GenePIK3CA (p110α), PIK3CB (p110β)
PDB4OVU, 3ZMS
Associated DiseasesAD, ALS, AMI, ARM, Aging
Known Drugs/CompoundsCAMP, RAPAMYCIN, QUERCETIN, RESVERATROL, Rehmannioside_A, LY294002
InteractionsLOX, MTOR, AKT, SQSTM1, EIF4EBP1, P62
KG Connections5220 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (28)

TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR
Score: 0.45
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
APOE-Dependent Autophagy Restoration
Score: 0.61
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57

Related Analyses (12)

Can biased TREM2 agonists selectively activate DAP12-SYK-PI3
molecular biology · failed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (9)

Network pharmacology analysis of QTJD active compounds and p
exploratory · proposed · Score: 0.90
S-equol-induced ferroptosis mechanism in TNBC cells
exploratory · proposed · Score: 0.90
VSMC cholesterol efflux and P2RY12 signaling
exploratory · proposed · Score: 0.90
P2RY12-MTOR pathway interaction in VSMCs
exploratory · proposed · Score: 0.85
In vivo autophagy modulation in atherosclerotic mice
validation · proposed · Score: 0.85

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in