protein 506 words KG: PLCG1 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

Phospholipase C Gamma 1 Protein

🔬 Protein Info
Gene SymbolPLCG1
AliasesPage for PLCG1
Protein FamilyPhospholipase C gamma family
Protein TypeEnzyme
FunctionPLCG1 is a phospholipase C isoform activated by receptor tyrosine kinases (RTKs).
Molecular Weight148.5 kDa
Amino Acids1290 aa
Pathwaysoncogenic pathway activation
UniProt IDP19174
GeneCardsPLCG1
Human Protein AtlasPLCG1
Associated Diseasesneurodegeneration
InteractionsLAMP2A, AUTOPHAGY, RB1, EGFR, TP53
KG Connections27 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

TP53 Gene
gene · KG edge: activates
RB1 — Retinoblastoma 1
gene · KG edge: activates
LAMP2A Gene
gene · KG edge: activates
GLI Gene Family
gene · KG edge: therapeutic_target
EP300 Gene
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

PLCG1 activates oncogenic pathway activation
PLCG1 activates LAMP2A
PLCG1 co_expressed_with TET2
PLCG1 co_expressed_with TP53
PLCG1 associated_with TET2
PLCG1 associated_with TP53
PLCG1 associated_with U2AF1
PLCG1 therapeutic_target Glioblastoma
PLCG1 therapeutic_target Cancer
PLCG1 activates Tumor