gene 519 words KG: NRAS 2026-03-24
kind:genesection:genesstate:published
Contents

NRAS Gene

🧬 Gene Info
Gene SymbolNRAS
Full NameNRAS Proto-Oncogene, GTPase
Chromosome1p13.2
FunctionNRAS is a member of the Ras family of small GTPases that cycles between active GTP-bound and inactive GDP-bound states.
Primary Expressionthe brain with high expression in the hippocampus, cortex, and cerebellum
Molecular Weight21.2 kDa
Amino Acids189 aa
PathwaysMAPK, PI3K, MAPK signaling
UniProt IDP01111
Ensembl IDENSG00000213281
GeneCardsNRAS
Human Protein AtlasNRAS
BrainNeurons, astrocytes, and microglia
SkinMelanocytes and keratinocytes
Immune SystemT cells, B cells, and myeloid cells
Associated DiseasesALS, Cancer, Epilepsy, Ms, Tumor
InteractionsSTAT1, POT1, HRAS, RHEB, BRAF, FGFR2
KG Connections172 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Epigenetic Memory Erasure via TET2 Activation
Score: 0.52
RNA Granule Nucleation Site Modulation
Score: 0.48
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Packard Center for ALS Research
institution · KG edge: activates
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: associated_with
DYRK1A Gene - Dual Specificity Tyrosine-Phosphorylation
gene · KG edge: associated_with
DNMT3A Gene
gene · KG edge: associated_with
cdkn2a
gene · KG edge: activates

Knowledge Graph (12 edges)

NRAS activates STAT1
NRAS associated_with IDH1
NRAS associated_with IDH2
NRAS activates POT1
NRAS binds SHOC2
NRAS associated_with BRAF
NRAS associated_with RAF1
NRAS associated_with CBL
NRAS associated_with OVERVIEW
NRAS activates HRAS