protein 1,771 words KG: PPAR 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

PPAR (Peroxisome Proliferator-Activated Receptor)

🔬 Protein Info
Gene SymbolPPAR
Full NamePPAR (Peroxisome Proliferator-Activated Receptor)
AliasesPeroxisome Proliferator-Activated Receptor
Protein TypeProtein
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionneurons, astrocytes, microglia, and oligodendrocytes, where they modulate critical processes including neuroinflammation, mit
PathwaysApoptosis, Autophagy, Differentiation, Epigenetic, Lipid Metabolism
UniProt IDSearch UniProt
GeneCardsPPAR
Human Protein AtlasPPAR
Associated DiseasesAD, ALS, AMI, ARDS, ARM
Known Drugs/CompoundsSDHHQ, kaempferol
InteractionsTNF, OCLN, MLCK, PINK1, NLRP3, LRRK2
KG Connections1015 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Adenosine-Astrocyte Metabolic Reset
Score: 0.56
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68

Related Analyses (29)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (4)

TUG C-terminal fragment nuclear interactions
exploratory · proposed · Score: 0.85
Pathway analysis of aminophylline effects on neuronal signal
exploratory · proposed · Score: 0.70
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
ALOX15 - Arachidonate 15-Lipoxygenase
gene · KG edge: inhibits
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: inhibits
ACE Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

PPAR protects_against NEUROPROTECTION
PPAR regulates NEURODEGENERATION
PPAR activates NEUROPROTECTION
PPAR implicated_in obesity
PPAR implicated_in ARDS
PPAR implicated_in degenerative disease
PPAR implicated_in neurodegenerative disease
PPAR activates TNF
PPAR activates OCLN
PPAR inhibits MLCK