| Gene Symbol | PTEN |
| Aliases | PTENPROTEIN |
| Chromosome | 10 |
| Function | is a critical tumor suppressor protein that negatively regulates the PI3K/AKT signaling pathway, playing essential roles in neuronal survival, synaptic plasticity, and cellular homeostasis[@pten2021]. |
| Molecular Weight | 47 kDa |
| Amino Acids | 403 aa |
| Pathways | Akt, Angiogenesis, Apoptosis, Autophagy, Chaperone |
| GeneCards | PTEN |
| Human Protein Atlas | PTEN |
| Strategy | Compound |
| PTEN inhibitors | BZLF1 |
| PTEN modulators | Diphenyl difluoroketone |
| AKT activators | SC79 |
| Biomarker | Sample |
| PTEN expression | Brain tissue |
| Associated Diseases | AD, ALI, ALS, AR-/NE- mCRPC, Aging |
| Known Drugs/Compounds | RAPAMYCIN, circRNA, dimethyl fumarate, quercetin, rapamycin, metformin |
| Interactions | PI3K, AKT, DDIT3, NBR1, EMD, MAPK8 |
| KG Connections | 2604 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |