protein 581 words KG: TRPA1 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

TRPA1 Protein

🔬 Protein Info
Gene SymbolTRPA1
Full NameTRPA1
Protein TypeProtein
Functionis a calcium-permeable non-selective cation channel characterized by 16-18 ankyrin repeat domains in its N-terminus, making it the most ankyrin-rich TRP channel[@nilius2014].
Molecular Weight108 kDa
Amino Acids959 aa
PathwaysEpigenetic, Nf-Κb, Toll-Like Receptor
UniProt IDSearch UniProt
GeneCardsTRPA1
Human Protein AtlasTRPA1
Associated DiseasesAlzheimer, Cancer, stroke
InteractionsSRC, SCN8A, AKT1, TRPM3, CREBBP, TNF
KG Connections254 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
LRP1-Dependent Tau Uptake Disruption
Score: 0.44
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.44
Extracellular Matrix Stiffness Modulation
Score: 0.43

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

See Also (8)

Alzheimer Indonesia
institution · KG edge: co_discussed
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
CACNA1C Gene
gene · KG edge: associated_with
CACNA1B Gene
gene · KG edge: associated_with
ANG — Angiogenin
gene · KG edge: regulates

Knowledge Graph (12 edges)

TRPA1 associated_with KCNMA1
TRPA1 associated_with TRPV1
TRPA1 associated_with KCNN4
TRPA1 associated_with KCNQ1
TRPA1 associated_with CACNA1C
TRPA1 expressed_in TRPM8
TRPA1 associated_with TRPM7
TRPA1 associated_with SCN5A
TRPA1 associated_with PIEZO1
TRPA1 associated_with SCN1A