protein 779 words KG: UBQLN2 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

UBQLN2 Protein

🔬 Protein Info
Gene SymbolUBQLN2
Protein FamilyUbiquilin family
FunctionContains disease-causing mutations (P497H, P506T)
Subcellular LocalizationCytoplasm, nucleus
Molecular Weight~66 kDa
Amino Acids600 aa
Exons11
PathwaysProtein Degradation
UniProt IDQ9R0R5
GeneCardsUBQLN2
Human Protein AtlasUBQLN2
Protein NameUbiquilin-2
GeneUBQLN2
PDB ID2KVR, 2L2B
Associated DiseasesALS, Amyotrophic Lateral Sclerosis, FTLD, Ms, NEURODEGENERATION
InteractionsHSP70, UNC5B, TIA1, HSPA1B, TDP-43, VAPB
KG Connections189 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (8)

Cryptic Exon Silencing Restoration
Score: 0.46
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Cross-Seeding Prevention Strategy
Score: 0.45
Lysosomal Positioning Dynamics Modulation
Score: 0.43
Glycine-Rich Domain Competitive Inhibition
Score: 0.43

Related Analyses (7)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
OPTN — Optineurin
gene · KG edge: associated_with
Genes
index · KG edge: associated_with
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: associated_with

Knowledge Graph (12 edges)

UBQLN2 activates PROTEIN_DEGRADATION
UBQLN2 associated_with OPTN
UBQLN2 associated_with GAIN
UBQLN2 associated_with C9ORF72
UBQLN2 interacts_with HSP70
UBQLN2 interacts_with UNC5B
UBQLN2 associated_with UBIQUITIN
UBQLN2 involved_in Protein Degradation
UBQLN2 activates TIA1
UBQLN2 activates HSPA1B