| Gene Symbol | SMAD2 |
| Full Name | SMAD Family Member 2 |
| Chromosome | 18q21.1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | (cytoplasmic vs. nuclear) is dynamically regulated by TGF-beta signaling[@schilling2008] |
| Amino Acids | 467 aa |
| Pathways | TGF-β, TGF-β signaling, TGF-β Signaling |
| UniProt ID | Q99716 |
| NCBI Gene ID | 4092 |
| Ensembl ID | ENSG00000175387 |
| OMIM | 601023 |
| GeneCards | SMAD2 |
| Human Protein Atlas | SMAD2 |
| MH1 domain (N-terminal) | Contains the DNA-binding domain that recognizes SMAD-binding elements (SBE) in target gene promoters |
| MH2 domain (C-terminal) | Mediates protein-protein interactions with receptors, co-SMADs, and transcriptional regulators |
| Associated Diseases | Aging, Als, Alzheimer, Cancer, Colorectal Cancer, Tumor |
| Known Drugs/Compounds | APIGENIN, lycopene |
| Interactions | AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOPTOSIS, APP |
| KG Connections | 259 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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