gene 1,922 words KG: TAB1
Contents

TAB1 — TAK1-Binding Protein 1

🧬 Gene Info
Gene SymbolTAB1
Full NameTAK1-Binding Protein 1
Chromosome11q13.1
Protein TypeAdaptor Protein
Functionis an adaptor protein that forms a critical complex with TAK1 (Transforming Growth Factor Beta-Activated Kinase 1).
Subcellular Localizationboth cytoplasm and nucleus
Molecular Weight110 kDa
Amino Acids504 aa
PathwaysNF-κB, MAPK, TGF-β, MAPK pathway, MAPK signaling
UniProt IDQ61240
NCBI Gene ID10454
Ensembl IDENSG00000100994
OMIM602475
GeneCardsTAB1
Human Protein AtlasTAB1
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsCANCER, CYTOKINES, IL1B, IL-6, INFLAMMATION, MAPK
KG Connections32 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Knowledge Graph (12 edges)

TAB1 activates IL1B
TAB1 activates MAPK14
TAB1 binds TRAF6
TAB1 activates MAPK3
TAB1 activates MAPK1
TAB1 expressed_in RELA
IRAK4 expressed_in TAB1
P38 inhibits TAB1
NLRP6 facilitates_degradation_via_TRIM21 TAB1
TAB1 upstream_of NF-κB signaling

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