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therapeutic 683 words KG: GABA 2026-03-21
kind:therapeuticsection:therapeuticsstate:published
Contents

Baclofen

💊 Therapeutic Info
NameBaclofen
SummaryPage for Baclofen
Key Genes/ProteinsGABARAP, LC3, MTOR, TFEB, RNA, ULK1
Related DiseasesALZHEIMER'S DISEASE
Related Pathwaysoxidative stress response
Linked Hypotheses5 hypotheses

Knowledge Graph

Related Hypotheses (6)

APOE-Dependent Autophagy Restoration
Score: 0.61Circadian-Synchronized Proteostasis Enhancement
Score: 0.58TFEB-Independent Autophagy Bypass
Score: 0.51Cell-Type Specific TFEB Modulation
Score: 0.48The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.40

Related Analyses (2)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (6)

iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90Trehalose-induced lysosomal changes and TFEB activation
exploratory · proposed · Score: 0.90Trehalose-induced lysosomal membrane permeabilization and TF
exploratory · proposed · Score: 0.90Functional validation of trehalose effects on misfolded prot
exploratory · proposed · Score: 0.85P2RY12-MTOR pathway interaction in VSMCs
exploratory · proposed · Score: 0.85

Knowledge Graph (12 edges)

GABA co_discussed JNK
GABA co_discussed LC3
GABA co_discussed LRRK2
GABA co_discussed MTOR
GABA co_discussed ULK1
GABA co_discussed HISTONE
GABA co_discussed ISCHEMIA
GABA co_discussed HTT
GABA co_discussed MITOCHONDRIA
GABA co_discussed MITOPHAGY
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