Scientific World Model

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

Showing 1–44 of 44 pages matching "causal chain"

⚙️ Gene-Mechanism-Therapy Causal ChainsKG

mechanism · 4,075 words · 104 hyp52 ana21 exp

⚙️ GBA1→GCase→Lysosome→PD Causal ChainKG

mechanism · 3,927 words · 14 hyp35 ana10 exp

🔀 SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathies Causal ChainKG

pathway · 3,707 words · 19 hyp37 ana27 exp

⚙️ TREM2→Microglial Dysfunction→Alzheimer's Disease Causal ChainKG

mechanism · 3,665 words · 93 hyp66 ana90 exp

⚙️ VPS35 Retromer Dysfunction Parkinson's Disease Causal ChainKG

mechanism · 3,215 words · 6 hyp43 ana60 exp

🔀 APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal ChainKG

pathway · 3,076 words · 60 hyp55 ana95 exp

⚙️ C9orf72→RNA/Dipeptide Repeat Pathology→ALS/FTD — Causal ChainKG

mechanism · 3,056 words · 22 hyp60 ana47 exp

⚙️ SOD1 Superoxide Dismutase 1 ALS Causal ChainKG

mechanism · 3,026 words · 10 hyp50 ana39 exp

⚙️ MAPT→Tau→Aggregation→PSP Causal ChainKG

mechanism · 3,015 words · 16 hyp36 ana28 exp

⚙️ RAB39B Endosomal-Lysosomal Dysfunction PD Causal ChainKG

mechanism · 2,779 words · 18 hyp36 ana7 exp

⚙️ FUS Gene-Mechanism-Therapy Causal Chain — ALS/FTDKG

mechanism · 2,751 words · 54 hyp62 ana30 exp

⚙️ HTT Gene-Mechanism-Therapy Causal Chain — Huntington's DiseaseKG

mechanism · 2,745 words · 53 hyp56 ana15 exp

⚙️ GRN Progranulin FTD Causal ChainKG

mechanism · 2,744 words · 32 hyp42 ana25 exp

⚙️ VCP→TDP-43→ALS/FTD Causal ChainKG

mechanism · 2,601 words · 11 hyp55 ana37 exp

🔀 SNCA→Alpha-synuclein→Parkinson's Disease Causal ChainKG

pathway · 2,538 words · 10 hyp42 ana83 exp

⚙️ OPTN (Optineurin) Mitophagy Dysfunction — ALS/FTD/PD Causal ChainKG

mechanism · 2,356 words · 150 hyp58 ana39 exp

⚙️ LRRK2→Kinase→Autophagy→PD Causal ChainKG

mechanism · 2,325 words · 13 hyp37 ana27 exp

⚙️ ATP13A2 Lysosomal Dysfunction Parkinson's Disease Causal ChainKG

mechanism · 2,302 words · 22 hyp44 ana64 exp

⚙️ PICALM→Clathrin-Mediated Endocytosis→Aβ Accumulation→AD Causal ChainKG

mechanism · 2,255 words · 45 hyp46 ana5 exp

⚙️ PSEN2 Presenilin 2 AD Causal ChainKG

mechanism · 2,012 words · 5 hyp32 ana4 exp

⚙️ BIN1→Endosomal Dysfunction→Tau Pathology→AD Causal ChainKG

mechanism · 1,896 words · 27 hyp42 ana9 exp

⚙️ PLCG2 Microglial Signaling Phagocytosis AD Causal ChainKG

mechanism · 1,757 words · 62 hyp37 ana3 exp

⚙️ ABCA1→Cholesterol Efflux→APOE Lipidation→Alzheimer's Disease Causal ChainKG

mechanism · 1,742 words · 64 hyp51 ana72 exp

⚙️ SORL1→APP Trafficking→Retromer Dysfunction→Aβ Accumulation→AD Causal ChainKG

mechanism · 1,688 words · 32 hyp44 ana11 exp

⚙️ DNAJC13→Endosomal Dysfunction→PD Causal ChainKG

mechanism · 1,643 words · 12 hyp36 ana5 exp

⚙️ PSEN1 Presenilin 1 AD Causal ChainKG

mechanism · 1,584 words · 18 hyp34 ana7 exp

⚙️ APOE Lipid Dysregulation Causal Chain in ADKG

mechanism · 1,560 words · 56 hyp46 ana60 exp

⚙️ CD2AP Synaptic Dysfunction Alzheimer's Disease Causal ChainKG

mechanism · 1,351 words · 60 hyp52 ana67 exp

⚙️ PARK7/DJ-1 Neuroprotection Pathway — Parkinson's Disease Causal ChainKG

mechanism · 1,319 words · 20 hyp45 ana60 exp

⚙️ CLU-Clusterin Amyloid Clearance Dysfunction AD Causal ChainKG

mechanism · 1,306 words · 38 hyp46 ana25 exp

⚙️ FBXO7→Mitophagy Dysfunction→Parkinson's Disease Causal ChainKG

mechanism · 1,260 words · 6 hyp43 ana61 exp

⚙️ CD33 Siglec Receptor Dysfunction Alzheimer's Disease Causal ChainKG

mechanism · 1,232 words · 63 hyp51 ana55 exp

⚙️ DCTN1 Dynactin Perry Syndrome Causal ChainKG

mechanism · 1,225 words · 7 hyp34 ana6 exp

⚙️ UCHL1 Ubiquitin-Proteasome Parkinson's Disease Causal ChainKG

mechanism · 1,201 words · 9 hyp47 ana61 exp

⚙️ CR1→Complement Activation→Synaptic Pruning→AD Causal ChainKG

mechanism · 1,179 words · 47 hyp44 ana2 exp

⚙️ SYNJ1→Synaptojanin-1→Synaptic Vesicle Recycling→PD Causal ChainKG

mechanism · 1,170 words · 29 hyp40 ana

⚙️ EPHA1→Ephrin Signaling→Synaptic Protection→AD Causal ChainKG

mechanism · 1,164 words · 86 hyp43 ana11 exp

⚙️ ABCA7 Lipid Transport and Microglial Phagocytosis AD Causal ChainKG

mechanism · 1,098 words · 74 hyp44 ana20 exp

⚙️ INPP5D SHIP1 Dysfunction Alzheimer's Disease Causal ChainKG

mechanism · 1,097 words · 41 hyp48 ana56 exp

⚙️ PTK2B→Pyk2→Synaptic Dysfunction→AD Causal ChainKG

mechanism · 1,071 words · 34 hyp40 ana5 exp

⚙️ CHCHD10 Mitochondrial Dysfunction — ALS/FTD Causal ChainKG

mechanism · 1,048 words · 41 hyp58 ana29 exp

⚙️ MS4A4A/MS4A6A → TREM2 Negative Regulation → Microglial Dysfunction → AD Causal ChainKG

mechanism · 1,022 words · 62 hyp56 ana9 exp

⚙️ GBA1 Gene-Mechanism-Therapy Causal Chains in NeurodegenerationKG

mechanism · 884 words · 1 exp

⚙️ TBK1 Autophagy and Neuroinflammation ALS/FTD Causal ChainKG

mechanism · 883 words · 16 hyp53 ana43 exp