🧫
Proposed experiment from debate on TDP-43 undergoes liquid-liquid phase separation that becomes pathological. Small
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-debate-adc63499d52e
🧫 Experiment Protocol
Falsification
Metadata
| experiment_type | falsification |
| source | {'type': 'manual', 'source_name': 'debate_extraction', 'extraction_date': '2026-04-16T01:00:16.908956Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['TDP'], 'diseases': ['Neurodegeneration']} |
| model_system | cell_line |
| summary | # Proposed experiment from debate on TDP-43 undergoes liquid-liquid phase separation that becomes pathological. Small ## Background and Rationale This falsification study critically examines the selec |
| replication_status | replicated |
| methodology_notes | **Phase 1: Cell Culture Preparation (Days 1-3)** • Culture HEK293T and SH-SY5Y neuroblastoma cell lines in DMEM with 10% FBS • Transfect cells with plasmids encoding wild-type TDP-43, pathological mut |
| primary_outcome | Determination of selectivity indices for each peptide mimetic, calculated as the ratio of IC50 for physiological TDP-43 function inhibition to IC50 for pathological aggregation suppression. |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from debate_extraction source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.908964'} |
🌍 Provenance Graph
8 nodes, 29 edges
derives from (15)
...and 10 more
Linked Artifacts (2739)