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Apolipoprotein E (ApoE)

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slug	proteins-apoe-protein
entity_type	protein
kg_node_id	APOEPROTEIN

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mentions🧪Cholesterol-CRISPR Convergence Therapy for Neurodegeneration90%

related🧪APOE Isoform Expression Across Glial Subtypes90%

related🧪Cholesterol-CRISPR Convergence Therapy for Neurodegeneration81%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer80%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones80%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction80%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy80%

mentions🧪Competitive APOE4 Domain Stabilization Peptides80%

see_also📖LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for APOE80%

see_also📖APOE4 (Apolipoprotein E4)75%

see_also📖Extracellular Vesicle and Tunneling Nanotube-Mediated Spread75%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer70%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones70%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction70%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy70%

mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides70%

mentions🧪Competitive APOE4 Domain Stabilization Peptides70%

mentions🧪APOE Isoform Expression Across Glial Subtypes70%

mentions🧪Circadian-Synchronized LRP1 Pathway Activation70%

mentions🧪Synthetic Biology BBB Endothelial Cell Reprogramming70%

related🧫AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi70%

related🧫AD Combination Therapy Trial: Anti-Aβ + Anti-Tau70%

related🧫Biomarker-Guided Sequential Therapy Selection in Alzheimer&#70%

related🧫Blood-Based Biomarker Panel for Early AD Detection70%

related🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise70%

related🧫Sex Differences in Alzheimer's Disease — mechanisms and70%

related🧫AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi70%

related🧫AD Combination Therapy Trial: Anti-Aβ + Anti-Tau70%

related🧫Biomarker-Guided Sequential Therapy Selection in Alzheimer&#70%

related🧫Blood-Based Biomarker Panel for Early AD Detection70%

related🧫Metal Ion Homeostasis Dysregulation in Alzheimer's Dise70%

related🧫Sex Differences in Alzheimer's Disease — mechanisms and70%

see_also📖Cell-Free DNA Biomarkers in Neurodegeneration70%

see_also📖Exosomal Biomarkers in Neurodegeneration70%

see_also📖Exosomal miR-155 in Neurodegeneration70%

see_also📖IL-6 (Interleukin-6) in Neurodegeneration70%

see_also📖Liquid Biopsy in Neurodegeneration70%

see_also📖Metabolomic Biomarkers in Neurodegeneration70%

see_also📖Neuroimaging Biomarkers for Neurodegeneration70%

see_also📖Synaptic Biomarkers in Neurodegeneration70%

see_also📖BEACoN Study - Biomarker Exploration in Aging, Cognition and70%

see_also📖LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy for 70%

see_also📖ALA-enriched Nutrition for APOE4 Carriers with MCI (NCT0739270%

see_also📖Olfactory Mucosa, Blood and Urine for Identification of Earl70%

see_also📖Swedish BioFINDER 2 Study: Biomarkers and Neurodegeneration 70%

see_also📖Beta-Propeller Protein-Associated Neurodegeneration (BPAN)70%

see_also📖China Neurodegeneration Epidemiology70%

see_also📖DALY Methodology — Neurodegeneration70%

see_also📖Disease Progression & Staging in Neurodegeneration70%

see_also📖Economic Burden — Neurodegeneration70%

see_also📖European Neurodegeneration Epidemiology70%

see_also📖Familial vs Sporadic Neurodegeneration Comparison70%

see_also📖Global Neurodegeneration Epidemiology70%

see_also📖India Neurodegeneration Epidemiology70%

see_also📖Japan Neurodegeneration Epidemiology70%

see_also📖Manganese-Related Neurodegeneration (Manganism)70%

see_also📖mitochondrial-dysfunction-neurodegeneration-comparison70%

see_also📖Mitochondrial Diseases and Neurodegeneration Comparison Matr70%

see_also📖Mitochondrial Membrane Protein-Associated Neurodegeneration 70%

see_also📖Neurodegeneration with Brain Iron Accumulation (NBIA)70%

see_also📖Potential Impact Measures — Neurodegeneration70%

see_also📖Pantothenate Kinase-Associated Neurodegeneration (PKAN)70%

see_also📖PLA2G6-Associated Neurodegeneration (PLAN)70%

see_also📖Sleep Disorders in Neurodegeneration70%

see_also📖US Neurodegeneration Epidemiology70%

see_also📖acetylcholine-signaling-neurodegeneration70%

see_also📖Advanced Glycation End Products in Neurodegeneration70%

see_also📖Advanced In Vitro Models for Neurodegeneration — Organoids, 70%

see_also📖Amylin Signaling in Neurodegeneration70%

see_also📖Antibody Therapy in Neurodegeneration70%

see_also📖Antisense Oligonucleotide (ASO) Therapy in Neurodegeneration70%

see_also📖Autosis Pathway in Neurodegeneration70%

see_also📖Axon Guidance Pathways in Neurodegeneration70%

see_also📖Basal Ganglia Circuit Dysfunction in Neurodegeneration70%

see_also📖becn1-autophagy-initiation-neurodegeneration-causal-chain70%

see_also📖CaMKII Signaling Pathway in Neurodegeneration70%

see_also📖Carbonic Anhydrase Modulator Therapy in Neurodegeneration70%

see_also📖Cerebral Amyloid Angiopathy in Neurodegeneration70%

see_also📖Cerebral Amyloid Angiopathy Pathway in Neurodegeneration70%

see_also📖Cholinergic System Dysfunction in Neurodegeneration70%

see_also📖Chrononutrition and Time-Restricted Eating in Neurodegenerat70%

see_also📖Neural Circuits in Neurodegeneration70%

see_also📖Cognitive Reserve and Resilience in Neurodegeneration70%

see_also📖Computational Disease Models for Neurodegeneration70%

see_also📖Convergent Pathways in Neurodegeneration70%

see_also📖Copper Homeostasis in Neurodegeneration70%

see_also📖COVID-19 Neurodegeneration Mechanism70%

see_also📖Diffusion MRI (DTI) in Neurodegeneration70%

see_also📖Digital Phenotyping in Neurodegeneration70%

see_also📖Down Syndrome Neurodegeneration Pathway70%

see_also📖Dystrophic Neurites in Neurodegeneration70%

see_also📖Endocannabinoid System in Neurodegeneration70%

see_also📖Endosomal-Lysosomal Pathway in Neurodegeneration70%

see_also📖Endosomal Sorting Defects in Neurodegeneration70%

see_also📖Endothelin Signaling Pathway in Neurodegeneration70%

see_also📖epigenetics-neurodegeneration70%

see_also📖ESCRT-III Inhibition by Alpha-Synuclein in Neurodegeneration70%

see_also📖FA2H-Associated Neurodegeneration Pathway70%

see_also📖Farnesoid X Receptor (FXR) Signaling in Neurodegeneration70%

see_also📖Galectin-3 Mechanism in Neurodegeneration70%

see_also📖Gangliosides in Neurodegeneration70%

see_also📖GDF15/GDF11 Signaling in Neurodegeneration70%

see_also📖GDNF Signaling Pathway in Neurodegeneration70%

see_also📖Ghrelin Signaling Pathway in Neurodegeneration70%

see_also📖Glucocorticoid Signaling Pathway in Neurodegeneration70%

see_also📖Glycosylation in Neurodegeneration70%

see_also📖gp130/IL-6 Family Cytokine Signaling in Neurodegeneration70%

see_also📖Hippocampal Neurogenesis in Neurodegeneration70%

see_also📖Histone Modification Pathways in Neurodegeneration70%

see_also📖HMGB1 Signaling in Neurodegeneration70%

see_also📖Homocysteine Neurotoxicity and Neurodegeneration70%

see_also📖IGF-1 Signaling Pathway in Neurodegeneration70%

see_also📖IL-1 Signaling Pathway in Neurodegeneration70%

see_also📖Integrated Stress Response in Neurodegeneration70%

see_also📖interleukin-6-signaling-neurodegeneration70%

see_also📖Intrinsic Apoptosis Pathway in Neurodegeneration70%

see_also📖Ion Channel Dysfunction in Neurodegeneration: Cross-Disease 70%

see_also📖Kidney-Brain Neurodegeneration Axis70%

see_also📖Lipid Dysregulation in Neurodegeneration70%

see_also📖Lipid Metabolism Dysregulation in Neurodegeneration70%

see_also📖Lysosomal Calcium Dysregulation in Neurodegeneration70%

see_also📖Magnetic Resonance Spectroscopy in Neurodegeneration70%

see_also📖Metal Homeostasis Dysregulation in Neurodegeneration70%

see_also📖Metal Homeostasis in Neurodegeneration70%

see_also📖Microglial Priming Pathway in Neurodegeneration70%

see_also📖MicroRNA Dysfunction in Neurodegeneration70%

see_also📖Mineralocorticoid Receptor Signaling in Neurodegeneration70%

see_also📖Mitochondrial Dynamics Pathway in Neurodegeneration70%

see_also📖Mitochondrial Fusion in Neurodegeneration70%

see_also📖Molecular Chaperones in Neurodegeneration70%

see_also📖mTOR Signaling in Neurodegeneration70%

see_also📖mTOR Signaling Pathway in Neurodegeneration70%

see_also📖Neural Circuit Disruption in Neurodegeneration70%

see_also📖Neurexin/Neuroligin Synaptic Adhesion Modulator Therapy in N70%

see_also📖Neurofilament Light Chain (NfL) Mechanism in Neurodegenerati70%

see_also📖Neuronal Hyperexcitability in Neurodegeneration70%

see_also📖Neuropil Threads in Neurodegeneration70%

see_also📖Neurotensin Signaling in Neurodegeneration70%

see_also📖Neurovascular Unit Dysfunction in Neurodegeneration70%

see_also📖NF-kB Signaling Pathway in Neurodegeneration70%

see_also📖Nitric Oxide Signaling in Neurodegeneration70%

see_also📖Noradrenergic Signaling Pathway in Neurodegeneration70%

see_also📖Neuropeptide Y Signaling in Neurodegeneration70%

see_also📖NRF2 Signaling Pathway in Neurodegeneration70%

see_also📖Nuclear Pore Complex Dysfunction in Neurodegeneration70%

see_also📖Orexin Signaling in Neurodegeneration70%

see_also📖OSK Reprogramming and Yamanaka Factors in Neurodegeneration70%

see_also📖P-Body (Processing Body) Pathway in Neurodegeneration70%

see_also📖Paranodal Dysfunction in Neurodegeneration70%

see_also📖Paraptosis in Neurodegeneration70%

see_also📖Parthanatos in Neurodegeneration70%

see_also📖Pericyte Loss in Neurodegeneration70%

see_also📖Peripheral Immune-Brain Crosstalk in Neurodegeneration70%

see_also📖PKR Pathway in Neurodegeneration70%

see_also📖PPAR Signaling Pathway in Neurodegeneration70%

see_also📖Prion Diseases in Neurodegeneration70%

see_also📖Prion-Like Spread in Neurodegeneration70%

see_also📖Prion Protein Metabolism in Neurodegeneration70%

see_also📖Progesterone Signaling Pathway in Neurodegeneration70%

see_also📖Prognostic Biomarkers in Neurodegeneration70%

see_also📖Protein Aggregation Comparison in Neurodegeneration70%

see_also📖Protein Aggregation Seeds in Neurodegeneration70%

see_also📖Protein O-GlcNAcylation Pathway in Neurodegeneration70%

see_also📖Cortical Involvement and Neurodegeneration in Progressive Su70%

see_also📖Purinergic Signaling in Neurodegeneration70%

see_also📖Quantum Biology and Coherent Energy Transfer in Neurodegener70%

see_also📖R-Loop Stress in Neurodegeneration70%

see_also📖RAN Translation in Neurodegeneration70%

see_also📖Retinal Degeneration Pathway in Neurodegeneration70%

see_also📖Ribosome Dysfunction in Neurodegeneration70%

see_also📖RNA Splicing in Neurodegeneration70%

see_also📖RNA-Targeted Therapies in Neurodegeneration70%

see_also📖Ribonuclease κ and Circular RNAs: A New Mechanism of Aging a70%

see_also📖S100 Protein Signaling Pathway in Neurodegeneration70%

see_also📖Senescent Cell Clearance in Neurodegeneration70%

see_also📖Serotonergic Dysfunction in Neurodegeneration70%

see_also📖Sex Differences in Neurodegeneration70%

see_also📖Short Chain Fatty Acids in Neurodegeneration70%

see_also📖Sigma-1 Receptor Signaling in Neurodegeneration70%

see_also📖Sirtuin-Mitochondrial Biogenesis Axis in Neurodegeneration70%

see_also📖Sleep Dysfunction in Neurodegeneration70%

see_also📖SUMOylation in Neurodegeneration70%

see_also📖synaptic-vesicle-cycling-neurodegeneration70%

see_also📖Synthetic Lethality and PARP Inhibition in Neurodegeneration70%

see_also📖T-Cell Dysfunction in Neurodegeneration70%

see_also📖Tertiary Lymphoid Organs in Neurodegeneration70%

see_also📖Therapeutic Targets in Neurodegeneration70%

see_also📖Transdiagnostic Proteomic Changes in Neurodegeneration70%

see_also📖ubiquitin-proteasome-dysfunction-neurodegeneration70%

see_also📖Ubiquitin-Proteasome System Dysfunction in Neurodegeneration70%

see_also📖Vagus Nerve Pathway in Neurodegeneration70%

see_also📖VEGF Signaling and Cerebral Angiogenesis in Neurodegeneratio70%

see_also📖vip-vasoactive-intestinal-peptide-signaling-neurodegeneratio70%

see_also📖WNK1-Bilirubin Signaling in Neuroinflammation and Neurodegen70%

see_also📖WNK1 Kinase in Neurodegeneration70%

see_also📖Wnt/β-Catenin Signaling Pathway in Neurodegeneration70%

mentions🧪Netrin-1 Gradient Restoration65%

mentions🧪Metabolic Circuit Breaker via Lipid Droplet Modulation65%

mentions🧪Circadian Rhythm Entrainment of Reactive Astrocytes65%

mentions🧪APOE-Mediated Synaptic Lipid Raft Stabilization65%

mentions🧪Matrix Stiffness Normalization via Targeted Lysyl Oxidase In65%

see_also📖nct0550878965%

see_also📖remternetug-anti-amyloid-alzheimers65%

see_also📖UPenn Observational Research Repository (NCT04715399)65%

see_also📖APOE2 (Apolipoprotein E2)65%

see_also📖APOE3 (Apolipoprotein E3)65%

related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer63%

related🧪APOE4 Allosteric Rescue via Small Molecule Chaperones63%

related🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction63%

related🧪Targeted APOE4-to-APOE3 Base Editing Therapy63%

related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides63%

related🧪Competitive APOE4 Domain Stabilization Peptides63%

related🧪Circadian-Synchronized LRP1 Pathway Activation63%

related🧪Synthetic Biology BBB Endothelial Cell Reprogramming63%

mentions🧪APOE Isoform Conversion Therapy60%

mentions🧪APOE4-Selective Lipid Nanoemulsion Therapy60%

mentions🔬What are the mechanisms underlying mechanistic role of apoe 60%

mentions🔬Lipid metabolism dysregulation and membrane integrity in Alz60%

mentions🔬Analysis question not specified60%

mentions🧫DDT/DDE exposure and cognitive function in Latina women60%

mentions🧫Microglial Aging and Immune Memory in Neurodegeneration — Tr60%

see_also📖Neurodegeneration60%

related🧪Metabolic Circuit Breaker via Lipid Droplet Modulation58%

related🧪Circadian Rhythm Entrainment of Reactive Astrocytes58%

related🧪APOE-Mediated Synaptic Lipid Raft Stabilization58%

related🧪Matrix Stiffness Normalization via Targeted Lysyl Oxidase In58%

related🧪APOE Isoform Conversion Therapy54%

related🧪APOE4-Selective Lipid Nanoemulsion Therapy54%

related🔬What are the mechanisms underlying mechanistic role of apoe 54%

related🔬Lipid metabolism dysregulation and membrane integrity in Alz54%

related🔬Analysis question not specified54%

related🧫DDT/DDE exposure and cognitive function in Latina women54%

related🧫Microglial Aging and Immune Memory in Neurodegeneration — Tr54%

mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

mentions🧪CYP46A1 Overexpression Gene Therapy50%

mentions🧪LRP1-Dependent Tau Uptake Disruption50%

mentions🧪Chaperone-Mediated APOE4 Refolding Enhancement50%

mentions🧪Pharmacological Enhancement of APOE4 Glycosylation50%

mentions🧪Membrane Cholesterol Gradient Modulators50%

mentions🧪TREM2-mediated microglial tau clearance enhancement50%

mentions🧪Fractalkine Axis Amplification via CX3CR1 Positive Allosteri50%

mentions🧪Reelin-Mediated Cytoskeletal Stabilization Protocol50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%

mentions🧪Heat Shock Protein 70 Disaggregase Amplification50%

mentions🧪Serine/Arginine-Rich Protein Kinase Modulation50%

mentions🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m50%

related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%

related🔬What are the mechanisms underlying astrocyte reactivity subt50%

related🔬What are the mechanisms underlying blood-brain barrier trans50%

related🔬What are the mechanisms underlying microglia-astrocyte cross50%

related🔬What are the mechanisms underlying apoe4 structural biology 50%

related🔬What are the mechanisms underlying mitochondrial transfer be50%

related🔬What are the mechanisms underlying perivascular spaces and g50%

related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%

related🔬What are the mechanisms underlying 4r-tau strain-specific sp50%

related🔬What are the mechanisms underlying tdp-43 phase separation t50%

related🔬What are the mechanisms underlying astrocyte reactivity subt50%

related🔬What are the mechanisms underlying blood-brain barrier trans50%

related🔬What are the mechanisms underlying microglia-astrocyte cross50%

related🔬What are the mechanisms underlying apoe4 structural biology 50%

related🔬What are the mechanisms underlying protein aggregation cross50%

related🔬What are the mechanisms underlying rna binding protein dysre50%

related🔬What are the mechanisms underlying mitochondrial transfer be50%

related🔬What are the mechanisms underlying perivascular spaces and g50%

related🔬Analyze circuit-level changes in neurodegeneration using All50%

related🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%

related🔬RNA binding protein dysregulation across ALS FTD and AD50%

related🧪Microbial Inflammasome Priming Prevention50%

related🔬What are the mechanisms underlying selective vulnerability o50%

related🔬Investigate how lipid raft composition (cholesterol metaboli50%

see_also📖Adipose-Derived Mesenchymal Stem Cell Therapy for Early Alzh50%

see_also📖NCT07477431 - Levetiracetam for Persons at Risk for Alzheime50%

see_also📖TRAILRUNNER-ALZ 1: Remternetug for Early Alzheimer's Di50%

see_also📖KarXT for Alzheimer's Disease Cognitive Impairment - MI50%

see_also📖A Phase 3, Randomised, Double-blinded, Placebo-controlled St50%

see_also📖Novartis Alzheimer's Disease Phase 2 Trial (NCT0709451650%

see_also📖Rotigotine and Rivastigmine Combination Therapy for Alzheime50%

see_also📖al002-trem2-agonist-alzheimers45%

see_also📖CORT108297 Phase 2 (NCT04601038) - Stress Attenuation in AD45%

see_also📖DBS Nucleus Basalis Trial (NCT07218081): Deep Brain Stimulat45%

see_also📖Donanemab TRAILBLAZER-ALZ 2 Trial45%

see_also📖MK-1167 Phase 2 AD Trial (MK-1167-008)45%

see_also📖A Placebo-Controlled, Double-Blind, Parallel-Group, 18-Month45%

see_also📖A Phase IIB, Randomized, Double-Blind, Placebo-Controlled, M45%

see_also📖A Phase 2 Double-Blind, Randomized, Placebo-Controlled Trial45%

see_also📖Trontinemab (RO7126209) Phase 3 Trial — TRONTIER 2 (NCT0717045%

see_also📖UB-311 Alzheimer's Vaccination Trial45%

see_also📖Cross-National Cancer-Dementia Correlation and Shared Diseas45%

see_also📖Cancer-Dementia Inverse Correlation: Epidemiological Evidenc45%

see_also📖SNCA — Alpha-Synuclein Gene Entity Page45%

see_also📖Alzheimer's Disease Mechanism Index45%

see_also📖NLRP3 Inflammasome Inhibitors for Parkinson's Disease45%

mentions📖Actinogen Medical40%

mentions📖University of Rostock40%

mentions📖sapienza-university-rome40%

mentions📖uniQure40%

mentions📖university-of-arizona40%

mentions📖university-of-utah40%

mentions🔬What are the mechanisms underlying protein aggregation cross40%

mentions🔬What are the mechanisms underlying rna binding protein dysre40%

mentions🔬RNA binding protein dysregulation across ALS FTD and AD40%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪Netrin-1 Gradient Restoration40%

related🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m40%

related🧪Heat Shock Protein 70 Disaggregase Amplification40%

related🧪Serine/Arginine-Rich Protein Kinase Modulation40%

related🧪APOE Isoform Conversion Therapy35%

related🧪Proteostasis Enhancement via APOE Chaperone Targeting35%

related🧪APOE Isoform Expression Across Glial Subtypes35%

related🔬What are the mechanisms underlying tdp-43 phase separation t30%