Microbial Metabolite-Mediated α-Synuclein Disaggregation

graph TD
    A["Gut Microbiome<br/>B. longum, F. prausnitzii<br/>A. muciniphila"] --> B["SCFA Production<br/>Butyrate, Propionate<br/>Acetate"]
    B --> C["Blood-Brain Barrier<br/>Crossing via MCT1/MCT2<br/>Transporters"]
    C --> D["HDAC Inhibition<br/>HDAC1, HDAC3, HDAC6<br/>Suppression"]
    D --> E["Histone Hyperacetylation<br/>H3/H4 Acetylation<br/>Chromatin Remodeling"]
    E --> F["HSF1/NF-Y Transcription<br/>Factor Activation"]
    F --> G["HSPA1A Upregulation<br/>Heat Shock Protein 70<br/>Expression"]
    C --> H["DNMT1 Inhibition<br/>DNA Methylation<br/>Reduction"]
    H --> I["Neuroprotective Gene<br/>Demethylation"]
    G --> J["Enhanced Protein<br/>Chaperone Activity"]
    I --> J
    J --> K["alpha-Synuclein<br/>Disaggregation"]
    L["alpha-Synuclein<br/>Pathological Aggregates"] --> K
    K --> M["Reduced Neuronal<br/>Toxicity"]
    M --> N["Neuroprotection<br/>Disease Modification"]
    O["Therapeutic Intervention<br/>SCFA Supplementation<br/>Probiotic Administration"] --> B