Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adenosine: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Adora1 | activates | protein | 0.90 |
| Adora2A | activates | protein | 0.90 |
| neurons | released_by | cell_type | 0.90 |
| astrocytes | released_by | cell_type | 0.80 |
| neural stem cells | released_by | cell_type | 0.70 |
| microglia | released_by | cell_type | 0.70 |
| visual cortex | active_in | brain_region | 0.60 |
| cerebellum | active_in | brain_region | 0.60 |
| blood-brain barrier | active_in | brain_region | 0.60 |
| T cells | released_by | cell_type | 0.60 |
| cortex | active_in | brain_region | 0.60 |
| GABAergic neurons | released_by | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| adenosine receptor | binds | receptor | 0.90 |
| AMPK | activates | gene | 0.90 |
| LC3 | activates | gene | 0.80 |
| ATP | activates | gene | 0.80 |
| AMPK | regulates | gene | 0.80 |
| ULK1 | activates | gene | 0.70 |
| SQSTM1 | activates | gene | 0.70 |
| ATG5 | activates | gene | 0.70 |
| ULK1 | interacts_with | gene | 0.70 |
| LC3 | interacts_with | gene | 0.70 |
| ATG5 | interacts_with | gene | 0.70 |
| LAMP1 | activates | gene | 0.70 |
| GAPDH | activates | gene | 0.70 |
| neuroinflammation | disrupts | disease | 0.70 |
| purinergic receptor | binds | receptor | 0.70 |
| MAP1LC3 | activates | gene | 0.70 |
| ATP | interacts_with | gene | 0.70 |
| AMPK | interacts_with | gene | 0.70 |
| GFP | activates | gene | 0.70 |
| RNA | regulates | gene | 0.70 |
| AMPK | implicated_in | gene | 0.70 |
| ABCA1 | activates | gene | 0.60 |
| P2RY12 | activates | gene | 0.60 |
| LOX | activates | gene | 0.60 |
| ACTB | activates | gene | 0.60 |
| ABCA1 | interacts_with | gene | 0.60 |
| P2RY12 | interacts_with | gene | 0.60 |
| LOX | interacts_with | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| CD38 | activates | gene | 0.60 |
| RAB7A | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| GSK3B | activates | gene | 0.60 |
| MYC | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| RAB7A | regulates | gene | 0.60 |
| MTOR | regulates | gene | 0.60 |
| GSK3B | regulates | gene | 0.60 |
| MYC | regulates | gene | 0.60 |
| LAMP1 | regulates | gene | 0.60 |
| BECN1 | regulates | gene | 0.60 |
| LC3 | regulates | gene | 0.60 |
| SQSTM1 | regulates | gene | 0.60 |
| GAPDH | regulates | gene | 0.60 |
| DRP1 | regulates | gene | 0.60 |
| AMBRA1 | regulates | gene | 0.60 |
| BNIP3L | regulates | gene | 0.60 |
| ADORA2A | regulates | gene | 0.60 |
| BCL2 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Adenosine-Astrocyte Metabolic Reset | 0.557 | neurodegeneration | Sleep disruption as cause and consequenc |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| A lineage-resolved molecular atlas of C. elegans embryogenesis at single-cell re [PMID:31488706] | Packer JS, Zhu Q, Huynh C, Sivaramakrish | Science | 2019 | 1 |
| Metabolic asymmetry and the global diversity of marine predators. [PMID:30679341] | Grady JM, Maitner BS, Winter AS, Kaschne | Science | 2019 | 1 |
| A Never-Ending Story of Per- and Polyfluoroalkyl Substances (PFASs)? [PMID:28224793] | Wang Z, DeWitt JC, Higgins CP, Cousins I | Environ Sci Technol | 2017 | 1 |
| Gene Expression by Mouse Inner Ear Hair Cells during Development. [PMID:25904789] | Scheffer DI, Shen J, Corey DP, Chen ZY | J Neurosci | 2015 | 1 |
| Chapter 6: Structural variation and medical genomics. [PMID:23300412] | Raphael BJ | PLoS Comput Biol | 2012 | 1 |
| Caffeine and adenosine. [PMID:20164566] | Ribeiro JA, Sebastião AM | J Alzheimers Dis | 2010 | 1 |
| De novo purine synthesis reprograms the macrophage inflammatory response and the [PMID:41756441] | Haskó G, Liu L, Németh ZH, Wagener G, Ak | Research square | 2026 | 0 |
| Parthenolide inhibits methamphetamine-induced depressive-like behavior by target [PMID:41795299] | Hui R, Feng T, Hou C, Xu J, Zhang R, Ji | Phytomedicine : international | 2026 | 0 |
| Adenosine 2A receptor-dependent activation of AMPK represses TH17 cell pathogeni [PMID:40986641] | Papadopoulou G, Valakos D, Polydouri I, | Science signaling | 2025 | 0 |
| Surface d-Band Modulation via Biodirected Mineralization Enables Nanoenzymes to [PMID:41073355] | Li X, Zhao Q, Feng X, Cui P, Yu J, Liang | ACS nano | 2025 | 0 |
| Endothelial adenosine receptor 2A loss alleviates diabetic vascular calcificatio [PMID:41067595] | Zhou Y, Zhao D, Ma Q, Xu J, Cai Y, Yang | Pharmacological research | 2025 | 0 |
| Targeting adenosine 2A receptor signaling suppresses vascular calcification by r [PMID:41201506] | Zhou Y, Zhao D, Ma Q, Lee S, Roh K, Cai | Pharmacological research | 2025 | 0 |
| Transcriptional control of pancreatic cancer immunosuppression by metabolic enzy [PMID:37291128] | Tang T, Huang X, Lu M, Zhang G, Han X, L | Nature communications | 2023 | 0 |
| Intestinal microbiota: A potential target for enhancing the antitumor efficacy a [PMID:33845122] | ["Luo B", "Zhang Y", "Zhang C", "Liu X", | Cancer letters | 2021 | 0 |
| Sepsis expands a CD39+ plasmablast population that promotes immunosuppression vi [PMID:34473957] | Nascimento DC, Viacava PR, Ferreira RG, | Immunity | 2021 | 0 |
| The integration of pharmacophore-based 3D QSAR modeling and virtual screening in [PMID:30605479] | ["Fan F", "Toledo Warshaviak D", "Hamade | PloS one | 2019 | 0 |
| Pharmacogenetics and induction/consolidation therapy toxicities in acute lymphob [PMID:26644204] | ["Franca R", "Rebora P", "Bertorello N", | The pharmacogenomics journal | 2017 | 0 |
| Cord blood gene expression supports that prenatal exposure to perfluoroalkyl sub [PMID:25812627] | ["Pennings J", "Jennen D", "Nygaard U", | Journal of immunotoxicology | 2016 | 0 |
| Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Simil [PMID:9160173] | ["Lennern\u00e4s H", "Fager G"] | Clinical pharmacokinetics | 1997 | 0 |