concept

BRSK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BRSK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

31Outgoing

10Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	BRSK2
Key Genes/Proteins	AKT, STAT3, NFKB, PIMREG, PIK3C3
Related Diseases	cancer_cell_survival, metastatic_potential
Related Pathways	autophagy, AMPK Signaling

Wiki Pages (8)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    BRSK2["BRSK2"]
    BRSK2 -->|"regulates"| autophagy["autophagy"]
    BRSK2 -->|"activates"| AKT["AKT"]
    BRSK2 -->|"activates"| STAT3["STAT3"]
    BRSK2 -->|"activates"| NFKB["NFKB"]
    BRSK2 -->|"phosphorylates"| PIMREG["PIMREG"]
    BRSK2 -->|"contributes to"| metastatic_potential["metastatic_potential"]
    miR_3960["miR-3960"] -->|"inhibits"| BRSK2
    SOD1["SOD1"] -->|"activates"| BRSK2
    AMPK["AMPK"] -->|"inhibits"| BRSK2
    NF__B["NF-KappaB"] -->|"regulates"| BRSK2
    EXOSOMES["EXOSOMES"] -->|"activates"| BRSK2
    CANCER["CANCER"] -->|"activates"| BRSK2

Outgoing (31)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
autophagy	regulates	pathway	0.90
AKT	activates	protein	0.90
STAT3	activates	protein	0.90
NFKB	activates	protein	0.90
cancer_cell_survival	associated_with	phenotype	0.90
PIMREG	phosphorylates	protein	0.90
PIMREG	mediates	protein	0.85
PIK3C3	associated_with	protein	0.80
metastatic_potential	contributes_to	phenotype	0.80
PIMREG	contributes_to	protein	0.80
PIMREG	degrades	protein	0.80
AMPK Signaling	involved_in	pathway	0.75
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
PIMREG	regulates	protein	0.64
Nf-Κb	regulates	pathway	0.60
SOD1	activates	gene	0.60
CANCER	activates	gene	0.60
EXOSOMES	activates	gene	0.60
Sod1	activates	pathway	0.60
AMPK	inhibits	gene	0.60
NF-ΚB	regulates	gene	0.60
AND	regulates	gene	0.60
Fibroblast	activates	cell_type	0.60
Ubiquitin	regulates	protein	0.60
NF-kB signaling	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
Fibroblast	expressed_in	cell_type	0.55
benchmark_ot_ad_answer_key:BRSK2	data_in	dataset_row	0.00

Incoming (10)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
miR-3960	inhibits	biomarker	0.90
miR_3960	inhibits	gene	0.72
AMPK	phosphorylates	protein	0.70
SOD1	activates	gene	0.60
AMPK	inhibits	gene	0.60
NF-ΚB	regulates	gene	0.60
EXOSOMES	activates	gene	0.60
CANCER	activates	gene	0.60
benchmark_ot_ad_answer_key:BRSK2	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

BRSK2

Understanding Entity Pages

Wiki Pages (8)

PIK3C3 (VPS34) Protein

PIK3C3 — Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (VPS34)

BRSK1 Gene

akt-protein

NF-κB p105 Protein

STAT3 Protein