CANX

Understanding Entity Pages

This page aggregates everything SciDEX knows about CANX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Calnexin is an ER membrane chaperone protein involved in protein folding, calcium homeostasis, and ER stress responses in neurodegeneration.

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graph TD
    CANX["CANX"] -->|"Interacts With"| ULK1["ULK1"]
    CANX["CANX"] -->|"Regulates"| autophagy["autophagy"]
    CANX["CANX"] -->|"Modulates"| cognitive_function["cognitive function"]
    CANX["CANX"] -->|"Expressed In"| hippocampal_neurons["hippocampal neurons"]
    CANX["CANX"] -->|"Interacts With"| Dementia["Dementia"]
    CANX["CANX"] -->|"Interacts With"| Cardiovascular["Cardiovascular"]
    CANX["CANX"] -->|"Interacts With"| Als["Als"]
    CANX["CANX"] -->|"Interacts With"| Alzheimer["Alzheimer"]
    WLS["WLS"] -->|"Interacts With"| CANX["CANX"]
    CAT["CAT"] -->|"Interacts With"| CANX["CANX"]
    OPTN["OPTN"] -->|"Interacts With"| CANX["CANX"]
    DNM1L["DNM1L"] -->|"Interacts With"| CANX["CANX"]
    MFN1["MFN1"] -->|"Interacts With"| CANX["CANX"]
    style CANX fill:#8d4900,color:#e0e0e0
    style ULK1 fill:#0d47a1,color:#e0e0e0
    style autophagy fill:#1b5e20,color:#e0e0e0
    style cognitive_function fill:#1b5e20,color:#e0e0e0
    style hippocampal_neurons fill:#795548,color:#e0e0e0
    style Dementia fill:#b71c1c,color:#e0e0e0
    style Cardiovascular fill:#b71c1c,color:#e0e0e0
    style Als fill:#b71c1c,color:#e0e0e0
    style Alzheimer fill:#b71c1c,color:#e0e0e0
    style WLS fill:#0d47a1,color:#e0e0e0
    style CAT fill:#8d4900,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style DNM1L fill:#8d4900,color:#e0e0e0
    style MFN1 fill:#8d4900,color:#e0e0e0