gene

CD163

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD163: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

322Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CD163 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with ALS, Aging, Als. Connected to 137 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD163
Full Name	CD163 Molecule (Hemoglobin Scavenger Receptor)
Aliases	Hemoglobin Scavenger Receptor
Chromosome	12p13.31
Protein Type	Receptor
Function	CD163 (Cluster of Differentiation 163), also known as the Hemoglobin Scavenger Receptor, is a member of the scavenger receptor family.
Pathways	TGF-β
UniProt ID	[Q86VB7](https://www.uniprot.org/uniprot/Q86VB7)
Ensembl ID	ENSG00000177575
GeneCards	CD163
Human Protein Atlas	CD163
Extracellular domain	9 scavenger receptor cysteine-rich (SRCR) domains
Transmembrane region	Single pass
Cytoplasmic tail	Signaling capabilities
Associated Diseases	ALS, Aging, Cancer, Inflammation, Ms, Neuroinflammation
Interactions	CD68, CX3CR1, CD36, NRF2, TNF, NEAT1
KG Connections	322 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD163["CD163"]
    CD163 -.biomarker for.-> Cancer["Cancer"]
    CD163 -.biomarker for.-> Als["Als"]
    CD163 -.biomarker for.-> Aging["Aging"]
    CD163 -.biomarker for.-> Ms["Ms"]
    CD163 -->|"activates"| Inflammation["Inflammation"]
    CD163 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    CD163 -->|"activates"| Tumor["Tumor"]
    CD163 -->|"activates"| Stroke["Stroke"]
    CD163 -->|"regulates"| Heart_Failure["Heart Failure"]
    CD36["CD36"] -->|"activates"| CD163
    NRF2["NRF2"] -->|"activates"| CD163
    CX3CR1["CX3CR1"] -->|"activates"| CD163
    TNF["TNF"] -->|"activates"| CD163
    CD68["CD68"] -->|"activates"| CD163
    AMPK["AMPK"] -->|"activates"| CD163
    CCR1["CCR1"] -->|"regulates"| CD163
    MRC1["MRC1"] -->|"regulates"| CD163
    C1QB["C1QB"] -->|"regulates"| CD163
    CD38["CD38"] -->|"regulates"| CD163

Outgoing (208)

Target	Relation	Type	Str
Inflammation	activates	disease	0.85
anti-inflammatory immune response	involved_in	process	0.80
Stroke	activates	disease	0.75
Als	therapeutic_target	disease	0.75
TYROBP	activates	gene	0.70
MICROGLIA	activates	gene	0.70
STROKE	activates	gene	0.70
Cancer	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Inflammation	associated_with	disease	0.65
Aging	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Neuroinflammation	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Heart Failure	regulates	disease	0.65
Als	regulates	disease	0.65
Hepatitis	regulates	disease	0.65
Cardiac	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Senescence	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Ms	associated_with	disease	0.65
ALS	biomarker_for	disease	0.65
Inflammation	degrades	disease	0.65
Multiple Sclerosis	biomarker_for	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Sepsis	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Cancer	associated_with	disease	0.65
MMP9	biomarker_for	gene	0.60
CD14	associated_with	gene	0.60
CD68	associated_with	gene	0.60
MMP2	biomarker_for	gene	0.60
CD68	activates	gene	0.60
CX3CR1	activates	gene	0.60
CD36	activates	gene	0.60
NRF2	activates	gene	0.60
TNF	activates	gene	0.60
CXCL10	regulates	gene	0.60
CD14	degrades	gene	0.60
NEAT1	activates	gene	0.60

Incoming (114)

Source	Relation	Type	Str
TNF	activates	gene	0.70
AMPK	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
CD36	activates	gene	0.60
NRF2	activates	gene	0.60
CX3CR1	activates	gene	0.60
CD68	associated_with	gene	0.60
CD14	associated_with	gene	0.60
CD68	activates	gene	0.60
CCR1	regulates	gene	0.60
MRC1	regulates	gene	0.60
C1QB	regulates	gene	0.60
CD38	regulates	gene	0.60
ICAM1	associated_with	gene	0.60
CXCL1	associated_with	gene	0.60
SOCS3	associated_with	gene	0.60
IL6	associated_with	gene	0.60
C5AR1	expressed_in	gene	0.60
TNF	therapeutic_target	gene	0.60
HSPA1A	associated_with	gene	0.60
SERPINA3	expressed_in	gene	0.60
CD4	activates	gene	0.60
LDLR	activates	gene	0.60
FOXP3	activates	gene	0.60
CD8	activates	gene	0.60
APOE	activates	gene	0.60
CCR6	activates	gene	0.60
CD4	associated_with	gene	0.60
LMNA	activates	gene	0.60
C1QA	activates	gene	0.60
CLU	activates	gene	0.60
CD14	degrades	gene	0.60
ARG1	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
STAT3	therapeutic_target	gene	0.60
MMP9	biomarker_for	gene	0.60
MMP2	biomarker_for	gene	0.60
CCR1	associated_with	gene	0.60
C1QB	associated_with	gene	0.60
AIF1	associated_with	gene	0.60
NEAT1	activates	gene	0.60
CYBB	associated_with	gene	0.60
PPAR	activates	gene	0.60
C3AR1	associated_with	gene	0.60
AKT	activates	gene	0.60
IL10	activates	gene	0.60
SPI1	activates	gene	0.60
PI3K	activates	gene	0.60
CCL5	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CD163

Understanding Entity Pages

Summary

Wiki Pages (18)

CD163 (Hemoglobin Scavenger Receptor)

Neuroinflammation Pathway

Section 132: Advanced Systems Immunology and Network Pharmacology in CBS/PSP

amyloid-beta-cellular-uptake

IL13 — Interleukin 13

Microglial Polarization

TREM2+ Border-Associated Macrophages

CCR1

Kupffer Cells

Innate Immune Reprogramming: NLRP3 + CD47 Checkpoint Blockade

HBB Gene

CCR6

Surveying Microglia

C1QB — Complement Component 1Q Beta

CNS Border-Associated Macrophages (BAMs)

Perivascular Macrophage Neuroprotection Therapy