gene

CCL20

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCL20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

156Connections
0Hypotheses
0Analyses
50Outgoing
41Incoming

Summary

CCL20 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Alzheimer. Connected to 78 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCCL20
Chromosome2q36.3
Protein TypeChemokine
FunctionCCL20 has distinct functions in immune and nervous systems:
Primary ExpressionCCR6 is expressed on Th17 cells, regulatory T cells, B cells, and dendritic cells
Molecular Weight~8 kDa
PathwaysPI3K, MAPK
NCBI Gene ID6384
GeneCardsCCL20
Human Protein AtlasCCL20
Protein ClassChemokine
Cell TypeExpression Level
[Neurons](/entities/neurons)Low-Moderate
[Astrocytes](/entities/astrocytes)High
MicrogliaModerate-High
Associated DiseasesAls, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes
Known Drugs/CompoundsIRN
InteractionsTLR4, MMP9, IL6, C1QA, LRP1, CXCL10
KG Connections156 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

CCL20 Gene

gene · 615 words

IL17B Gene

gene · 1855 words

IL26 Gene

gene · 1787 words

Choroid Plexus Epithelial Cells

cell · 1373 words

IL17F Gene

gene · 921 words

CCR6

gene · 870 words

Pathway Diagram

flowchart TD
    IRN["IRN"] -.->|"inhibits"| CCL20["CCL20"]
    CCL20["CCL20"] -->|"therapeutic target"| Ms["Ms"]
    CCL20["CCL20"] -->|"therapeutic target"| Als["Als"]
    CCL20["CCL20"] -->|"regulates"| Als["Als"]
    CCL20["CCL20"] -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    CCL20["CCL20"] -->|"regulates"| Inflammation["Inflammation"]
    CCL20["CCL20"] -->|"associated with"| Hepatitis["Hepatitis"]
    CCL20["CCL20"] -->|"associated with"| Glioblastoma["Glioblastoma"]
    CCL20["CCL20"] -->|"associated with"| Alzheimer["Alzheimer"]
    CCL20["CCL20"] -->|"associated with"| Obesity["Obesity"]
    CCL20["CCL20"] -->|"associated with"| Diabetes["Diabetes"]
    CCL20["CCL20"] -->|"associated with"| Stroke["Stroke"]
    style IRN fill:#6d3000,stroke:#333,color:#e0e0e0
    style CCL20 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Glioblastoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Obesity fill:#ef5350,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (115)

TargetRelationTypeStr
Subarachnoid Hemorrhageassociated_withdisease0.80
NF-ΚBactivatesgene0.70
Nf-Κbactivatespathway0.70
Mstherapeutic_targetdisease0.65
Alstherapeutic_targetdisease0.65

Incoming (41)

SourceRelationTypeStr
ABLIM1upstream_ofprotein0.90
Isorhynchophyllinedownregulatescompound0.90
NF-KBregulatespathway0.90
IRNinhibitsdrug0.72
MMP9activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found