Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CCL20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CCL20 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Alzheimer. Connected to 78 entities in the SciDEX knowledge graph.
| Gene Symbol | CCL20 |
| Chromosome | 2q36.3 |
| Protein Type | Chemokine |
| Function | CCL20 has distinct functions in immune and nervous systems: |
| Primary Expression | CCR6 is expressed on Th17 cells, regulatory T cells, B cells, and dendritic cells |
| Molecular Weight | ~8 kDa |
| Pathways | PI3K, MAPK |
| NCBI Gene ID | 6384 |
| GeneCards | CCL20 |
| Human Protein Atlas | CCL20 |
| Protein Class | Chemokine |
| Cell Type | Expression Level |
| [Neurons](/entities/neurons) | Low-Moderate |
| [Astrocytes](/entities/astrocytes) | High |
| Microglia | Moderate-High |
| Associated Diseases | Als, Alzheimer, Autoimmune, Cancer, Carcinoma, Diabetes |
| Known Drugs/Compounds | IRN |
| Interactions | TLR4, MMP9, IL6, C1QA, LRP1, CXCL10 |
| KG Connections | 156 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
flowchart TD
IRN["IRN"] -.->|"inhibits"| CCL20["CCL20"]
CCL20["CCL20"] -->|"therapeutic target"| Ms["Ms"]
CCL20["CCL20"] -->|"therapeutic target"| Als["Als"]
CCL20["CCL20"] -->|"regulates"| Als["Als"]
CCL20["CCL20"] -->|"regulates"| Neuroinflammation["Neuroinflammation"]
CCL20["CCL20"] -->|"regulates"| Inflammation["Inflammation"]
CCL20["CCL20"] -->|"associated with"| Hepatitis["Hepatitis"]
CCL20["CCL20"] -->|"associated with"| Glioblastoma["Glioblastoma"]
CCL20["CCL20"] -->|"associated with"| Alzheimer["Alzheimer"]
CCL20["CCL20"] -->|"associated with"| Obesity["Obesity"]
CCL20["CCL20"] -->|"associated with"| Diabetes["Diabetes"]
CCL20["CCL20"] -->|"associated with"| Stroke["Stroke"]
style IRN fill:#6d3000,stroke:#333,color:#e0e0e0
style CCL20 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
style Als fill:#ef5350,stroke:#333,color:#e0e0e0
style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
style Glioblastoma fill:#ef5350,stroke:#333,color:#e0e0e0
style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
style Obesity fill:#ef5350,stroke:#333,color:#e0e0e0
style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Subarachnoid Hemorrhage | associated_with | disease | 0.80 |
| NF-ΚB | activates | gene | 0.70 |
| Nf-Κb | activates | pathway | 0.70 |
| Ms | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Hepatitis | associated_with | disease | 0.65 |
| Glioblastoma | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Obesity | associated_with | disease | 0.65 |
| Diabetes | associated_with | disease | 0.65 |
| Stroke | associated_with | disease | 0.65 |
| Multiple Sclerosis | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Fibrosis | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Leukemia | associated_with | disease | 0.65 |
| Autoimmune | associated_with | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Colorectal Cancer | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Cardiovascular | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| TLR4 | activates | gene | 0.60 |
| MMP9 | activates | gene | 0.60 |
| IL6 | activates | gene | 0.60 |
| STAT3 | regulates | gene | 0.60 |
| CX3CL1 | regulates | gene | 0.60 |
| CXCL10 | regulates | gene | 0.60 |
| C1QA | activates | gene | 0.60 |
| LRP1 | activates | gene | 0.60 |
| CD38 | associated_with | gene | 0.60 |
| FOXP3 | associated_with | gene | 0.60 |
| PPARG | associated_with | gene | 0.60 |
| NOTCH1 | associated_with | gene | 0.60 |
| SMAD6 | associated_with | gene | 0.60 |
| FOXP2 | associated_with | gene | 0.60 |
| GATA3 | associated_with | gene | 0.60 |
| ATF6 | associated_with | gene | 0.60 |
| MAF | associated_with | gene | 0.60 |
| CXCL10 | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ABLIM1 | upstream_of | protein | 0.90 |
| Isorhynchophylline | downregulates | compound | 0.90 |
| NF-KB | regulates | pathway | 0.90 |
| IRN | inhibits | drug | 0.72 |
| MMP9 | activates | gene | 0.60 |
| IL6 | activates | gene | 0.60 |
| RORA | associated_with | gene | 0.60 |
| BMP7 | associated_with | gene | 0.60 |
| CX3CR1 | associated_with | gene | 0.60 |
| AHR | associated_with | gene | 0.60 |
| EP300 | associated_with | gene | 0.60 |
| JUN | associated_with | gene | 0.60 |
| JAK2 | associated_with | gene | 0.60 |
| TLR4 | activates | gene | 0.60 |
| FOXO1 | activates | gene | 0.60 |
| STAT3 | activates | gene | 0.60 |
| SOCS3 | activates | gene | 0.60 |
| LRP1 | activates | gene | 0.60 |
| CXCL8 | associated_with | gene | 0.60 |
| MMP3 | associated_with | gene | 0.60 |
| ICAM1 | associated_with | gene | 0.60 |
| HMGCR | therapeutic_target | gene | 0.60 |
| C1QA | activates | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| CYTOKINES | associated_with | gene | 0.60 |
| DIABETES MELLITUS | associated_with | gene | 0.60 |
| MICRORNAS | associated_with | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| AND | activates | gene | 0.60 |
| MIRNAS | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| RNA | therapeutic_target | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ICAM1 | expressed_in | gene | 0.50 |
| C1QA | co_discussed | gene | 0.50 |
| ICAM1 | interacts_with | gene | 0.50 |
| RNA | regulates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||